The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis

Abstract To investigate the change trends of plasma D-dimer during catheter-directed thrombolysis (CDT) in acute lower limb ischemia (ALI) patients and their clinical value. A retrospective review of patients with ALI who received CDT was carried out. The repeated measurements of plasma D-dimer were...

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Autores principales:	Xiaochun Liu, Hailiang Xie, Guofu Zheng, Yuanfei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/757b9b1ab4e04dcea5aeced89570b7b7
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spelling	oai:doaj.org-article:757b9b1ab4e04dcea5aeced89570b7b72021-12-02T16:51:14ZThe plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis10.1038/s41598-021-89905-x2045-2322https://doaj.org/article/757b9b1ab4e04dcea5aeced89570b7b72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89905-xhttps://doaj.org/toc/2045-2322Abstract To investigate the change trends of plasma D-dimer during catheter-directed thrombolysis (CDT) in acute lower limb ischemia (ALI) patients and their clinical value. A retrospective review of patients with ALI who received CDT was carried out. The repeated measurements of plasma D-dimer were analyzed by generalized estimating equations (GEEs) and the change trends of D-dimer were analyzed by spline regression approach. A total of 150 patients were included. Among them, 3 days of CDT was ineffective in 41 cases, effective in 33 cases and markedly effective in 76 cases. The results of GEEs analysis showed that serum D-dimer changed significantly with time (time effect, P < 0.001). Serum D-dimer levels of patients with different treatment outcomes were different after treatment (group effect, P < 0.001), and serum D-dimer levels in these three groups showed different trends over time (group*time effect, P < 0.001). The different trends in serum D-dimer level with time after treatment in the three groups could be directly seen in the spline regression curve (P < 0.001). The plasma D-dimer changes regularly during CDT for ALI. We can predict the efficacy of CDT and guide adjustments of the therapeutic regimen according to the trend of D-dimer changes during thrombolysis.Xiaochun LiuHailiang XieGuofu ZhengYuanfei LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaochun Liu Hailiang Xie Guofu Zheng Yuanfei Liu The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
description	Abstract To investigate the change trends of plasma D-dimer during catheter-directed thrombolysis (CDT) in acute lower limb ischemia (ALI) patients and their clinical value. A retrospective review of patients with ALI who received CDT was carried out. The repeated measurements of plasma D-dimer were analyzed by generalized estimating equations (GEEs) and the change trends of D-dimer were analyzed by spline regression approach. A total of 150 patients were included. Among them, 3 days of CDT was ineffective in 41 cases, effective in 33 cases and markedly effective in 76 cases. The results of GEEs analysis showed that serum D-dimer changed significantly with time (time effect, P < 0.001). Serum D-dimer levels of patients with different treatment outcomes were different after treatment (group effect, P < 0.001), and serum D-dimer levels in these three groups showed different trends over time (group*time effect, P < 0.001). The different trends in serum D-dimer level with time after treatment in the three groups could be directly seen in the spline regression curve (P < 0.001). The plasma D-dimer changes regularly during CDT for ALI. We can predict the efficacy of CDT and guide adjustments of the therapeutic regimen according to the trend of D-dimer changes during thrombolysis.
format	article
author	Xiaochun Liu Hailiang Xie Guofu Zheng Yuanfei Liu
author_facet	Xiaochun Liu Hailiang Xie Guofu Zheng Yuanfei Liu
author_sort	Xiaochun Liu
title	The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
title_short	The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
title_full	The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
title_fullStr	The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
title_full_unstemmed	The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
title_sort	plasma d-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/757b9b1ab4e04dcea5aeced89570b7b7
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The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis

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