A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion

Pre-malignant cells harbouring oncogenic mutations can populate and spread throughout a tissue. Here, using a rainbow mouse system, the authors explore how clonal expansion in the mouse intestine might explain high levels of intra-tumoural heterogeneity observed in the disease.

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Autores principales:	Peter G. Boone, Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, Mei Lang Flowers, Richard J. von Furstenberg, Barry R. Stripp, Pankaj Agarwal, Alexander D. Borowsky, Robert D. Cardiff, Larry S. Barak, Marc G. Caron, H. Kim Lyerly, Joshua C. Snyder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/757eeb180b694b92bb92c9f6266b5ea1
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spelling	oai:doaj.org-article:757eeb180b694b92bb92c9f6266b5ea12021-12-02T14:35:50ZA cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion10.1038/s41467-019-13330-y2041-1723https://doaj.org/article/757eeb180b694b92bb92c9f6266b5ea12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13330-yhttps://doaj.org/toc/2041-1723Pre-malignant cells harbouring oncogenic mutations can populate and spread throughout a tissue. Here, using a rainbow mouse system, the authors explore how clonal expansion in the mouse intestine might explain high levels of intra-tumoural heterogeneity observed in the disease.Peter G. BooneLauren K. RochelleJoshua D. GinzelVeronica LubkovWendy L. RobertsP. J. NichollsCheryl BockMei Lang FlowersRichard J. von FurstenbergBarry R. StrippPankaj AgarwalAlexander D. BorowskyRobert D. CardiffLarry S. BarakMarc G. CaronH. Kim LyerlyJoshua C. SnyderNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter G. Boone Lauren K. Rochelle Joshua D. Ginzel Veronica Lubkov Wendy L. Roberts P. J. Nicholls Cheryl Bock Mei Lang Flowers Richard J. von Furstenberg Barry R. Stripp Pankaj Agarwal Alexander D. Borowsky Robert D. Cardiff Larry S. Barak Marc G. Caron H. Kim Lyerly Joshua C. Snyder A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
description	Pre-malignant cells harbouring oncogenic mutations can populate and spread throughout a tissue. Here, using a rainbow mouse system, the authors explore how clonal expansion in the mouse intestine might explain high levels of intra-tumoural heterogeneity observed in the disease.
format	article
author	Peter G. Boone Lauren K. Rochelle Joshua D. Ginzel Veronica Lubkov Wendy L. Roberts P. J. Nicholls Cheryl Bock Mei Lang Flowers Richard J. von Furstenberg Barry R. Stripp Pankaj Agarwal Alexander D. Borowsky Robert D. Cardiff Larry S. Barak Marc G. Caron H. Kim Lyerly Joshua C. Snyder
author_facet	Peter G. Boone Lauren K. Rochelle Joshua D. Ginzel Veronica Lubkov Wendy L. Roberts P. J. Nicholls Cheryl Bock Mei Lang Flowers Richard J. von Furstenberg Barry R. Stripp Pankaj Agarwal Alexander D. Borowsky Robert D. Cardiff Larry S. Barak Marc G. Caron H. Kim Lyerly Joshua C. Snyder
author_sort	Peter G. Boone
title	A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
title_short	A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
title_full	A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
title_fullStr	A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
title_full_unstemmed	A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
title_sort	cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/757eeb180b694b92bb92c9f6266b5ea1
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A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion

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