A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion

A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion

Pre-malignant cells harbouring oncogenic mutations can populate and spread throughout a tissue. Here, using a rainbow mouse system, the authors explore how clonal expansion in the mouse intestine might explain high levels of intra-tumoural heterogeneity observed in the disease.

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Bibliographic Details
Main Authors: Peter G. Boone, Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, Mei Lang Flowers, Richard J. von Furstenberg, Barry R. Stripp, Pankaj Agarwal, Alexander D. Borowsky, Robert D. Cardiff, Larry S. Barak, Marc G. Caron, H. Kim Lyerly, Joshua C. Snyder
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/757eeb180b694b92bb92c9f6266b5ea1
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https://doaj.org/article/757eeb180b694b92bb92c9f6266b5ea1

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