Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance

KRAS mutations drive resistance to diverse targeted therapies. In this study, the authors show that the rare codons of KRAS, yielding low oncogene expression, can be overcome to drive resistance to anti-EGFR therapy in CRC through upregulation of global translation or through selection of more poten...

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Autores principales:	Moiez Ali, Erin Kaltenbrun, Grace R. Anderson, Sarah Jo Stephens, Sabrina Arena, Alberto Bardelli, Christopher M. Counter, Kris C. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/758523a625184d568c02dd0233d59ad9
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spelling	oai:doaj.org-article:758523a625184d568c02dd0233d59ad92021-12-02T14:41:11ZCodon bias imposes a targetable limitation on KRAS-driven therapeutic resistance10.1038/ncomms156172041-1723https://doaj.org/article/758523a625184d568c02dd0233d59ad92017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15617https://doaj.org/toc/2041-1723KRAS mutations drive resistance to diverse targeted therapies. In this study, the authors show that the rare codons of KRAS, yielding low oncogene expression, can be overcome to drive resistance to anti-EGFR therapy in CRC through upregulation of global translation or through selection of more potent KRASQ61mutations.Moiez AliErin KaltenbrunGrace R. AndersonSarah Jo StephensSabrina ArenaAlberto BardelliChristopher M. CounterKris C. WoodNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moiez Ali Erin Kaltenbrun Grace R. Anderson Sarah Jo Stephens Sabrina Arena Alberto Bardelli Christopher M. Counter Kris C. Wood Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
description	KRAS mutations drive resistance to diverse targeted therapies. In this study, the authors show that the rare codons of KRAS, yielding low oncogene expression, can be overcome to drive resistance to anti-EGFR therapy in CRC through upregulation of global translation or through selection of more potent KRASQ61mutations.
format	article
author	Moiez Ali Erin Kaltenbrun Grace R. Anderson Sarah Jo Stephens Sabrina Arena Alberto Bardelli Christopher M. Counter Kris C. Wood
author_facet	Moiez Ali Erin Kaltenbrun Grace R. Anderson Sarah Jo Stephens Sabrina Arena Alberto Bardelli Christopher M. Counter Kris C. Wood
author_sort	Moiez Ali
title	Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
title_short	Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
title_full	Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
title_fullStr	Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
title_full_unstemmed	Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
title_sort	codon bias imposes a targetable limitation on kras-driven therapeutic resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/758523a625184d568c02dd0233d59ad9
work_keys_str_mv	AT moiezali codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT erinkaltenbrun codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT graceranderson codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT sarahjostephens codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT sabrinaarena codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT albertobardelli codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT christophermcounter codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance AT kriscwood codonbiasimposesatargetablelimitationonkrasdriventherapeuticresistance
_version_	1718389998260060160

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance

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