The interplays between autophagy and apoptosis induced by enterovirus 71.

<h4>Background</h4>Enterovirus 71 (EV71) is the causative agent of human diseases with distinct severity, from mild hand, foot and mouth disease to severe neurological syndromes, such as encephalitis and meningitis. The lack of understanding of viral pathogenesis as well as lack of effic...

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Autores principales:	Xueyan Xi, Xiaoyan Zhang, Bei Wang, Tao Wang, Ji Wang, He Huang, Jianwei Wang, Qi Jin, Zhendong Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7585827f396a48b3a6bcb6381fb89164
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spelling	oai:doaj.org-article:7585827f396a48b3a6bcb6381fb891642021-11-18T07:56:44ZThe interplays between autophagy and apoptosis induced by enterovirus 71.1932-620310.1371/journal.pone.0056966https://doaj.org/article/7585827f396a48b3a6bcb6381fb891642013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437282/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Enterovirus 71 (EV71) is the causative agent of human diseases with distinct severity, from mild hand, foot and mouth disease to severe neurological syndromes, such as encephalitis and meningitis. The lack of understanding of viral pathogenesis as well as lack of efficient vaccine and drugs against this virus impedes the control of EV71 infection. EV71 virus induces autophagy and apoptosis; however, the relationship between EV71-induced autophagy and apoptosis as well as the influence of autophagy and apoptosis on virus virulence remains unclear.<h4>Methodology/principal findings</h4>In this study, it was observed that the Anhui strain of EV71 induced autophagy and apoptosis in human rhabdomyosarcoma (RD-A) cells. Additionally, by either applying chemical inhibitors or knocking down single essential autophagic or apoptotic genes, inhibition of EV71 induced autophagy inhibited the apoptosis both at the autophagosome formation stage and autophagy execution stage. However, inhibition of autophagy at the stage of autophagosome and lysosome fusion promoted apoptosis. In reverse, the inhibition of EV71-induced apoptosis contributed to the conversion of microtubule-associated protein 1 light chain 3-I (LC3-I) to LC3-II and degradation of sequestosome 1 (SQSTM1/P62). Furthermore, the inhibition of autophagy in the autophagsome formation stage or apoptosis decreased the release of EV71 viral particles.<h4>Conclusions/significance</h4>In conclusion, the results of this study not only revealed novel aspect of the interplay between autophagy and apoptosis in EV71 infection, but also provided a new insight to control EV71 infection.Xueyan XiXiaoyan ZhangBei WangTao WangJi WangHe HuangJianwei WangQi JinZhendong ZhaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56966 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueyan Xi Xiaoyan Zhang Bei Wang Tao Wang Ji Wang He Huang Jianwei Wang Qi Jin Zhendong Zhao The interplays between autophagy and apoptosis induced by enterovirus 71.
description	<h4>Background</h4>Enterovirus 71 (EV71) is the causative agent of human diseases with distinct severity, from mild hand, foot and mouth disease to severe neurological syndromes, such as encephalitis and meningitis. The lack of understanding of viral pathogenesis as well as lack of efficient vaccine and drugs against this virus impedes the control of EV71 infection. EV71 virus induces autophagy and apoptosis; however, the relationship between EV71-induced autophagy and apoptosis as well as the influence of autophagy and apoptosis on virus virulence remains unclear.<h4>Methodology/principal findings</h4>In this study, it was observed that the Anhui strain of EV71 induced autophagy and apoptosis in human rhabdomyosarcoma (RD-A) cells. Additionally, by either applying chemical inhibitors or knocking down single essential autophagic or apoptotic genes, inhibition of EV71 induced autophagy inhibited the apoptosis both at the autophagosome formation stage and autophagy execution stage. However, inhibition of autophagy at the stage of autophagosome and lysosome fusion promoted apoptosis. In reverse, the inhibition of EV71-induced apoptosis contributed to the conversion of microtubule-associated protein 1 light chain 3-I (LC3-I) to LC3-II and degradation of sequestosome 1 (SQSTM1/P62). Furthermore, the inhibition of autophagy in the autophagsome formation stage or apoptosis decreased the release of EV71 viral particles.<h4>Conclusions/significance</h4>In conclusion, the results of this study not only revealed novel aspect of the interplay between autophagy and apoptosis in EV71 infection, but also provided a new insight to control EV71 infection.
format	article
author	Xueyan Xi Xiaoyan Zhang Bei Wang Tao Wang Ji Wang He Huang Jianwei Wang Qi Jin Zhendong Zhao
author_facet	Xueyan Xi Xiaoyan Zhang Bei Wang Tao Wang Ji Wang He Huang Jianwei Wang Qi Jin Zhendong Zhao
author_sort	Xueyan Xi
title	The interplays between autophagy and apoptosis induced by enterovirus 71.
title_short	The interplays between autophagy and apoptosis induced by enterovirus 71.
title_full	The interplays between autophagy and apoptosis induced by enterovirus 71.
title_fullStr	The interplays between autophagy and apoptosis induced by enterovirus 71.
title_full_unstemmed	The interplays between autophagy and apoptosis induced by enterovirus 71.
title_sort	interplays between autophagy and apoptosis induced by enterovirus 71.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7585827f396a48b3a6bcb6381fb89164
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_version_	1718422738310266880

The interplays between autophagy and apoptosis induced by enterovirus 71.

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