The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner
TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity.
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Nature Portfolio
2019
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oai:doaj.org-article:759408e47c5a4d35885debb0d56f6eb32021-12-02T14:39:18ZThe tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner10.1038/s41467-019-12661-02041-1723https://doaj.org/article/759408e47c5a4d35885debb0d56f6eb32019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12661-0https://doaj.org/toc/2041-1723TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity.Subramanya SrikantanYilun DengZi-Ming ChengAnqi LuoYuejuan QinQing GaoGlaiza-Mae Sande-DocorSifan TaoXingyu ZhangNathan HarperChris E. ShannonMarcel FourcaudotZhi LiBalakuntalam S. KasinathStephen HarrisonSunil AhujaRobert L. ReddickLily Q. DongMuhammad Abdul-GhaniLuke NortonRicardo C. T. AguiarPatricia L. M. DahiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Subramanya Srikantan Yilun Deng Zi-Ming Cheng Anqi Luo Yuejuan Qin Qing Gao Glaiza-Mae Sande-Docor Sifan Tao Xingyu Zhang Nathan Harper Chris E. Shannon Marcel Fourcaudot Zhi Li Balakuntalam S. Kasinath Stephen Harrison Sunil Ahuja Robert L. Reddick Lily Q. Dong Muhammad Abdul-Ghani Luke Norton Ricardo C. T. Aguiar Patricia L. M. Dahia The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| description |
TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity. |
| format |
article |
| author |
Subramanya Srikantan Yilun Deng Zi-Ming Cheng Anqi Luo Yuejuan Qin Qing Gao Glaiza-Mae Sande-Docor Sifan Tao Xingyu Zhang Nathan Harper Chris E. Shannon Marcel Fourcaudot Zhi Li Balakuntalam S. Kasinath Stephen Harrison Sunil Ahuja Robert L. Reddick Lily Q. Dong Muhammad Abdul-Ghani Luke Norton Ricardo C. T. Aguiar Patricia L. M. Dahia |
| author_facet |
Subramanya Srikantan Yilun Deng Zi-Ming Cheng Anqi Luo Yuejuan Qin Qing Gao Glaiza-Mae Sande-Docor Sifan Tao Xingyu Zhang Nathan Harper Chris E. Shannon Marcel Fourcaudot Zhi Li Balakuntalam S. Kasinath Stephen Harrison Sunil Ahuja Robert L. Reddick Lily Q. Dong Muhammad Abdul-Ghani Luke Norton Ricardo C. T. Aguiar Patricia L. M. Dahia |
| author_sort |
Subramanya Srikantan |
| title |
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| title_short |
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| title_full |
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| title_fullStr |
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| title_full_unstemmed |
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
| title_sort |
tumor suppressor tmem127 regulates insulin sensitivity in a tissue-specific manner |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/759408e47c5a4d35885debb0d56f6eb3 |
| work_keys_str_mv |
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1718390662078922752 |