COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY

Objective: To explore the prokinetic effect of Ranitidine, to compare it with the prokinetic effect of Neostigmine and to observe the potentiating prokinetic effect of Ranitidine and Neostigmine in combination. Study Design: Randomised controlled trial (experimental study). Place and Duration...

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Autores principales:	Aroosa Ishtiaq Butt, Asma Khan, Wardha Mazhar, Qamar uz Zaman Khan, Imrana Maqsood
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	prokinetic ranitidine neostigmine powerlab Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.2677 https://doaj.org/article/7594af3a12e24e918065e2a263b65f2d
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spelling	oai:doaj.org-article:7594af3a12e24e918065e2a263b65f2d2021-12-02T19:11:54ZCOMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDYhttps://doi.org/10.51253/pafmj.v71iSuppl-1.26770030-96482411-8842https://doaj.org/article/7594af3a12e24e918065e2a263b65f2d2021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2677https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To explore the prokinetic effect of Ranitidine, to compare it with the prokinetic effect of Neostigmine and to observe the potentiating prokinetic effect of Ranitidine and Neostigmine in combination. Study Design: Randomised controlled trial (experimental study). Place and Duration of Study: Multi disciplinary centre, Army Medical College, Rawalpindi, from Jan to Dec 2015. Methodology: Experiments were performed on three groups of rabbits (n=6) and Cumulative dose response curves were plotted using isolated duodenal tissue on power lab (USA). In the first two groups of experiments, cumulative concentrations of Neostigmine and Ranitidine were studied separately with neostigmine acting as a control and in the third group the potentiating effect of a fixed dose of ranitidine on neostigmine was evaluated. Results: Neostigmine’s response was taken as 100 percent and Ranitidine’s response when compared to it came out to be 197 percent. The dose response curve of Neostigmine was shifted to the left and upwards in the presence of Ranitidine. The percent response with Neostigmine alone was taken as 100 percent and increased to 212 percent when the tissue was pre-treated with Ranitidine. Conclusion: Our study has indicated that Ranitidine has marked prokinetic effect which is found to be greater than Neostigmine. It is also inferred that Ranitidine can potentiate the prokinetic effect of Neostigmine.Aroosa Ishtiaq ButtAsma KhanWardha MazharQamar uz Zaman KhanImrana MaqsoodArmy Medical College RawalpindiarticleprokineticranitidineneostigminepowerlabMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 66-70 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prokinetic ranitidine neostigmine powerlab Medicine R Medicine (General) R5-920
spellingShingle	prokinetic ranitidine neostigmine powerlab Medicine R Medicine (General) R5-920 Aroosa Ishtiaq Butt Asma Khan Wardha Mazhar Qamar uz Zaman Khan Imrana Maqsood COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
description	Objective: To explore the prokinetic effect of Ranitidine, to compare it with the prokinetic effect of Neostigmine and to observe the potentiating prokinetic effect of Ranitidine and Neostigmine in combination. Study Design: Randomised controlled trial (experimental study). Place and Duration of Study: Multi disciplinary centre, Army Medical College, Rawalpindi, from Jan to Dec 2015. Methodology: Experiments were performed on three groups of rabbits (n=6) and Cumulative dose response curves were plotted using isolated duodenal tissue on power lab (USA). In the first two groups of experiments, cumulative concentrations of Neostigmine and Ranitidine were studied separately with neostigmine acting as a control and in the third group the potentiating effect of a fixed dose of ranitidine on neostigmine was evaluated. Results: Neostigmine’s response was taken as 100 percent and Ranitidine’s response when compared to it came out to be 197 percent. The dose response curve of Neostigmine was shifted to the left and upwards in the presence of Ranitidine. The percent response with Neostigmine alone was taken as 100 percent and increased to 212 percent when the tissue was pre-treated with Ranitidine. Conclusion: Our study has indicated that Ranitidine has marked prokinetic effect which is found to be greater than Neostigmine. It is also inferred that Ranitidine can potentiate the prokinetic effect of Neostigmine.
format	article
author	Aroosa Ishtiaq Butt Asma Khan Wardha Mazhar Qamar uz Zaman Khan Imrana Maqsood
author_facet	Aroosa Ishtiaq Butt Asma Khan Wardha Mazhar Qamar uz Zaman Khan Imrana Maqsood
author_sort	Aroosa Ishtiaq Butt
title	COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
title_short	COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
title_full	COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
title_fullStr	COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
title_full_unstemmed	COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY
title_sort	comparison of prokinetic activity of ranitidine and neostigmine alone and in combination- an in vitro study
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.2677 https://doaj.org/article/7594af3a12e24e918065e2a263b65f2d
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COMPARISON OF PROKINETIC ACTIVITY OF RANITIDINE AND NEOSTIGMINE ALONE AND IN COMBINATION- AN IN VITRO STUDY

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