The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

ObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging sy...

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Autores principales:	Eder da Silva Dolens, Mauricio Rocha Dourado, Alhadi Almangush, Tuula A. Salo, Clarissa Araujo Gurgel Rocha, Sabrina Daniela da Silva, Peter A. Brennan, Ricardo D. Coletta
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	histopathological markers prognosis oral cancer systematic review meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/75978f15a5574aa386b303e55a7637da
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spelling	oai:doaj.org-article:75978f15a5574aa386b303e55a7637da2021-11-10T05:35:58ZThe Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis2234-943X10.3389/fonc.2021.784924https://doaj.org/article/75978f15a5574aa386b303e55a7637da2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.784924/fullhttps://doaj.org/toc/2234-943XObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature.MethodsA systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.ResultsThe study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.ConclusionOur results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.Eder da Silva DolensEder da Silva DolensMauricio Rocha DouradoAlhadi AlmangushAlhadi AlmangushTuula A. SaloTuula A. SaloTuula A. SaloClarissa Araujo Gurgel RochaClarissa Araujo Gurgel RochaSabrina Daniela da SilvaSabrina Daniela da SilvaPeter A. BrennanRicardo D. ColettaRicardo D. ColettaFrontiers Media S.A.articlehistopathological markersprognosisoral cancersystematic reviewmeta-analysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	histopathological markers prognosis oral cancer systematic review meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	histopathological markers prognosis oral cancer systematic review meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Eder da Silva Dolens Eder da Silva Dolens Mauricio Rocha Dourado Alhadi Almangush Alhadi Almangush Tuula A. Salo Tuula A. Salo Tuula A. Salo Clarissa Araujo Gurgel Rocha Clarissa Araujo Gurgel Rocha Sabrina Daniela da Silva Sabrina Daniela da Silva Peter A. Brennan Ricardo D. Coletta Ricardo D. Coletta The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
description	ObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature.MethodsA systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.ResultsThe study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.ConclusionOur results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.
format	article
author	Eder da Silva Dolens Eder da Silva Dolens Mauricio Rocha Dourado Alhadi Almangush Alhadi Almangush Tuula A. Salo Tuula A. Salo Tuula A. Salo Clarissa Araujo Gurgel Rocha Clarissa Araujo Gurgel Rocha Sabrina Daniela da Silva Sabrina Daniela da Silva Peter A. Brennan Ricardo D. Coletta Ricardo D. Coletta
author_facet	Eder da Silva Dolens Eder da Silva Dolens Mauricio Rocha Dourado Alhadi Almangush Alhadi Almangush Tuula A. Salo Tuula A. Salo Tuula A. Salo Clarissa Araujo Gurgel Rocha Clarissa Araujo Gurgel Rocha Sabrina Daniela da Silva Sabrina Daniela da Silva Peter A. Brennan Ricardo D. Coletta Ricardo D. Coletta
author_sort	Eder da Silva Dolens
title	The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_short	The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_full	The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_fullStr	The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_full_unstemmed	The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_sort	impact of histopathological features on the prognosis of oral squamous cell carcinoma: a comprehensive review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/75978f15a5574aa386b303e55a7637da
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The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

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