A review of fibrin and fibrin composites for bone tissue engineering

Alireza Noori,1 Seyed Jamal Ashrafi,2 Roza Vaez-Ghaemi,3 Ashraf Hatamian-Zaremi,4 Thomas J Webster5 1Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 2School of Medicine, Shahroud University of M...

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Autores principales:	Noori A, Ashrafi SJ, Vaez-Ghaemi R, Hatamian-Zaremi A, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	fibrin bone tissue engineering nanocomposites and tissue regeneration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/759c1eb887cb497fb67f41ad9271f552
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spelling	oai:doaj.org-article:759c1eb887cb497fb67f41ad9271f5522021-12-02T04:33:04ZA review of fibrin and fibrin composites for bone tissue engineering1178-2013https://doaj.org/article/759c1eb887cb497fb67f41ad9271f5522017-07-01T00:00:00Zhttps://www.dovepress.com/a-review-of-fibrin-and-fibrin-composites-for-bone-tissue-engineering-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Alireza Noori,1 Seyed Jamal Ashrafi,2 Roza Vaez-Ghaemi,3 Ashraf Hatamian-Zaremi,4 Thomas J Webster5 1Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 2School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran; 3Department of Chemical and Biological Engineering, Faculty of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada; 4Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA Abstract: Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications. Keywords: fibrin, fibrinogen, injectable hydrogel, fibrin preparation, fibrin beads, fibrin coating, nanofibrous scaffold, bone repair Noori AAshrafi SJVaez-Ghaemi RHatamian-Zaremi AWebster TJDove Medical Pressarticlefibrinbonetissue engineeringnanocompositesand tissue regenerationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4937-4961 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrin bone tissue engineering nanocomposites and tissue regeneration Medicine (General) R5-920
spellingShingle	fibrin bone tissue engineering nanocomposites and tissue regeneration Medicine (General) R5-920 Noori A Ashrafi SJ Vaez-Ghaemi R Hatamian-Zaremi A Webster TJ A review of fibrin and fibrin composites for bone tissue engineering
description	Alireza Noori,1 Seyed Jamal Ashrafi,2 Roza Vaez-Ghaemi,3 Ashraf Hatamian-Zaremi,4 Thomas J Webster5 1Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 2School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran; 3Department of Chemical and Biological Engineering, Faculty of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada; 4Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA Abstract: Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications. Keywords: fibrin, fibrinogen, injectable hydrogel, fibrin preparation, fibrin beads, fibrin coating, nanofibrous scaffold, bone repair
format	article
author	Noori A Ashrafi SJ Vaez-Ghaemi R Hatamian-Zaremi A Webster TJ
author_facet	Noori A Ashrafi SJ Vaez-Ghaemi R Hatamian-Zaremi A Webster TJ
author_sort	Noori A
title	A review of fibrin and fibrin composites for bone tissue engineering
title_short	A review of fibrin and fibrin composites for bone tissue engineering
title_full	A review of fibrin and fibrin composites for bone tissue engineering
title_fullStr	A review of fibrin and fibrin composites for bone tissue engineering
title_full_unstemmed	A review of fibrin and fibrin composites for bone tissue engineering
title_sort	review of fibrin and fibrin composites for bone tissue engineering
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/759c1eb887cb497fb67f41ad9271f552
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A review of fibrin and fibrin composites for bone tissue engineering

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