Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells t...

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Autores principales:	Md Afjalus Siraj, Md. Arman Islam, Md. Abdullah Al Fahad, Habiba Rahman Kheya, Jianbo Xiao, Jesus Simal-Gandara
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Keap1 Nrf2 ARE terpenoid cancer chemoprevention Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/75a12f1ee73c4ac8bc9e0f91fb75f2b4
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spelling	oai:doaj.org-article:75a12f1ee73c4ac8bc9e0f91fb75f2b42021-11-25T16:38:31ZCancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update10.3390/app1122108062076-3417https://doaj.org/article/75a12f1ee73c4ac8bc9e0f91fb75f2b42021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10806https://doaj.org/toc/2076-3417ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system.Md Afjalus SirajMd. Arman IslamMd. Abdullah Al FahadHabiba Rahman KheyaJianbo XiaoJesus Simal-GandaraMDPI AGarticleKeap1Nrf2AREterpenoidcancerchemopreventionTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10806, p 10806 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Keap1 Nrf2 ARE terpenoid cancer chemoprevention Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	Keap1 Nrf2 ARE terpenoid cancer chemoprevention Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
description	ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system.
format	article
author	Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara
author_facet	Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara
author_sort	Md Afjalus Siraj
title	Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
title_short	Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
title_full	Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
title_fullStr	Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
title_full_unstemmed	Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
title_sort	cancer chemopreventive role of dietary terpenoids by modulating keap1-nrf2-are signaling system—a comprehensive update
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/75a12f1ee73c4ac8bc9e0f91fb75f2b4
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Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

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