Liver retransplantation in adults: the largest multicenter Italian study.

Liver retransplantation in adults: the largest multicenter Italian study.

This study is the largest Italian survey on liver retransplantations (RET). Data report on 167 adult patients who received 2 grafts, 16 who received 3 grafts, and one who received 4 grafts over a 11 yr period.There was no statistically significant difference in graft survival after the first or the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Umberto Maggi, Enzo Andorno, Giorgio Rossi, Luciano De Carlis, Umberto Cillo, Fabrizio Bresadola, Vincenzo Mazzaferro, Andrea Risaliti, Paolo Bertoli, Dario Consonni, Francesco Barretta, Tullia De Feo, Mario Scalamogna
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/75a535ebd3b74ad59ecbaf539a5dc43a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:75a535ebd3b74ad59ecbaf539a5dc43a
record_format dspace
spelling oai:doaj.org-article:75a535ebd3b74ad59ecbaf539a5dc43a2021-11-18T08:13:05ZLiver retransplantation in adults: the largest multicenter Italian study.1932-620310.1371/journal.pone.0046643https://doaj.org/article/75a535ebd3b74ad59ecbaf539a5dc43a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071604/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This study is the largest Italian survey on liver retransplantations (RET). Data report on 167 adult patients who received 2 grafts, 16 who received 3 grafts, and one who received 4 grafts over a 11 yr period.There was no statistically significant difference in graft survival after the first or the second RET (52, 40, and 29% vs 44, 36, and 18% at 1,5,and 10 yr, respectively: Log-Rank test, p = 0.30).Survivals at 1, 5, and 10 years of patients who underwent 2 (n = 151) or 3 (n = 15) RETs, were 65, 48,and 39% vs 59, 44, and 30%, respectively (p = 0.59).Multivariate analysis of survival showed that only the type of graft (whole vs reduced) was associated with a statistically significant difference (HR = 3.77, Wald test p = 0. 05); the donor age appeared to be a relevant factor as well, although the difference was not statistically significant (HR = 1.91, Wald test p = 0.08).Though late RETs have better results on long term survival relative to early RETs, no statistically significant difference can be found in early results, till three years after RET.Considering late first RETs (interval>30 days from previous transplantation) with whole grafts the difference in graft survival in RETs due to HCV recurrence (n = 17) was not significantly different from RETs due to other causes (n = 53) (65-58 and 31% vs 66-57 and 28% respectively at 1-5 and 10 years, p = 0.66).Umberto MaggiEnzo AndornoGiorgio RossiLuciano De CarlisUmberto CilloFabrizio BresadolaVincenzo MazzaferroAndrea RisalitiPaolo BertoliDario ConsonniFrancesco BarrettaTullia De FeoMario ScalamognaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46643 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Umberto Maggi
Enzo Andorno
Giorgio Rossi
Luciano De Carlis
Umberto Cillo
Fabrizio Bresadola
Vincenzo Mazzaferro
Andrea Risaliti
Paolo Bertoli
Dario Consonni
Francesco Barretta
Tullia De Feo
Mario Scalamogna
Liver retransplantation in adults: the largest multicenter Italian study.
description This study is the largest Italian survey on liver retransplantations (RET). Data report on 167 adult patients who received 2 grafts, 16 who received 3 grafts, and one who received 4 grafts over a 11 yr period.There was no statistically significant difference in graft survival after the first or the second RET (52, 40, and 29% vs 44, 36, and 18% at 1,5,and 10 yr, respectively: Log-Rank test, p = 0.30).Survivals at 1, 5, and 10 years of patients who underwent 2 (n = 151) or 3 (n = 15) RETs, were 65, 48,and 39% vs 59, 44, and 30%, respectively (p = 0.59).Multivariate analysis of survival showed that only the type of graft (whole vs reduced) was associated with a statistically significant difference (HR = 3.77, Wald test p = 0. 05); the donor age appeared to be a relevant factor as well, although the difference was not statistically significant (HR = 1.91, Wald test p = 0.08).Though late RETs have better results on long term survival relative to early RETs, no statistically significant difference can be found in early results, till three years after RET.Considering late first RETs (interval>30 days from previous transplantation) with whole grafts the difference in graft survival in RETs due to HCV recurrence (n = 17) was not significantly different from RETs due to other causes (n = 53) (65-58 and 31% vs 66-57 and 28% respectively at 1-5 and 10 years, p = 0.66).
format article
author Umberto Maggi
Enzo Andorno
Giorgio Rossi
Luciano De Carlis
Umberto Cillo
Fabrizio Bresadola
Vincenzo Mazzaferro
Andrea Risaliti
Paolo Bertoli
Dario Consonni
Francesco Barretta
Tullia De Feo
Mario Scalamogna
author_facet Umberto Maggi
Enzo Andorno
Giorgio Rossi
Luciano De Carlis
Umberto Cillo
Fabrizio Bresadola
Vincenzo Mazzaferro
Andrea Risaliti
Paolo Bertoli
Dario Consonni
Francesco Barretta
Tullia De Feo
Mario Scalamogna
author_sort Umberto Maggi
title Liver retransplantation in adults: the largest multicenter Italian study.
title_short Liver retransplantation in adults: the largest multicenter Italian study.
title_full Liver retransplantation in adults: the largest multicenter Italian study.
title_fullStr Liver retransplantation in adults: the largest multicenter Italian study.
title_full_unstemmed Liver retransplantation in adults: the largest multicenter Italian study.
title_sort liver retransplantation in adults: the largest multicenter italian study.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/75a535ebd3b74ad59ecbaf539a5dc43a
work_keys_str_mv AT umbertomaggi liverretransplantationinadultsthelargestmulticenteritalianstudy
AT enzoandorno liverretransplantationinadultsthelargestmulticenteritalianstudy
AT giorgiorossi liverretransplantationinadultsthelargestmulticenteritalianstudy
AT lucianodecarlis liverretransplantationinadultsthelargestmulticenteritalianstudy
AT umbertocillo liverretransplantationinadultsthelargestmulticenteritalianstudy
AT fabriziobresadola liverretransplantationinadultsthelargestmulticenteritalianstudy
AT vincenzomazzaferro liverretransplantationinadultsthelargestmulticenteritalianstudy
AT andrearisaliti liverretransplantationinadultsthelargestmulticenteritalianstudy
AT paolobertoli liverretransplantationinadultsthelargestmulticenteritalianstudy
AT darioconsonni liverretransplantationinadultsthelargestmulticenteritalianstudy
AT francescobarretta liverretransplantationinadultsthelargestmulticenteritalianstudy
AT tulliadefeo liverretransplantationinadultsthelargestmulticenteritalianstudy
AT marioscalamogna liverretransplantationinadultsthelargestmulticenteritalianstudy
_version_ 1718422049616035840

Ejemplares similares