French experience of 2009 A/H1N1v influenza in pregnant women.
<h4>Background</h4>The first reports on the pandemic influenza 2009 A/H1N1v from the USA, Mexico, and Australia indicated that this disease was associated with a high mortality in pregnant women. The aim of this study was to describe and compare the characteristics of severe critically i...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2010
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/75a57b265c9c4811ab4081a5e087652e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:75a57b265c9c4811ab4081a5e087652e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:75a57b265c9c4811ab4081a5e087652e2021-11-18T07:03:39ZFrench experience of 2009 A/H1N1v influenza in pregnant women.1932-620310.1371/journal.pone.0013112https://doaj.org/article/75a57b265c9c4811ab4081a5e087652e2010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957195/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The first reports on the pandemic influenza 2009 A/H1N1v from the USA, Mexico, and Australia indicated that this disease was associated with a high mortality in pregnant women. The aim of this study was to describe and compare the characteristics of severe critically ill and non-severe pregnant women with 2009 A/H1N1v-related illness in France.<h4>Methodology/principal findings</h4>A national registry was created to screen pregnant women with laboratory-confirmed 2009 A/H1N1v influenza. Three hundred and fifteen patients from 46 French hospitals were included: 40 patients were admitted to intensive care units (severe outcomes), 111 were hospitalized in obstetric or medical wards (moderate outcomes), and 164 were outpatients (mild outcomes). The 2009 A/H1N1v influenza illness occurred during all pregnancy trimesters, but most women (54%), notably the severe patients (70%), were in the third trimester. Among the severe patients, twenty (50%) underwent mechanical ventilation, and eleven (28%) were treated with extracorporeal membrane oxygenation. Three women died from A/H1N1v influenza. We found a strong association between the development of a severe outcome and both co-existing illnesses (adjusted odds ratio [OR], 5.1; 95% confidence interval [CI], 2.2-11.8) and a delay in oseltamivir treatment after the onset of symptoms (>3 or 5 days) (adjusted OR, 4.8; 95% CI, 1.9-12.1 and 61.2, 95% CI; 14.4-261.3, respectively). Among the 140 deliveries after 22 weeks of gestation known to date, 19 neonates (14%) were admitted to a neonatal intensive care unit, mainly for preterm delivery, and two neonates died. None of these neonates developed 2009 A/H1N1v infection.<h4>Conclusions</h4>This series confirms the high incidence of complications in pregnant women infected with pandemic A/H1N1v observed in other countries but depicts a lower overall maternal and neonatal mortality and morbidity than indicated in the USA or Australia. Moreover, our data demonstrate the benefit of early oseltamivir treatment in this specific population.Grégory DubarElie AzriaAntoine TesnièreHervé DupontCamille Le RayThomas BaugnonSophie MatheronDominique LutonJean-Christophe RichardOdile LaunayVassilis TsatsarisFrançois GoffinetAlexandre MignonFrench Registry on 2009 A/H1N1v during pregnancyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Grégory Dubar Elie Azria Antoine Tesnière Hervé Dupont Camille Le Ray Thomas Baugnon Sophie Matheron Dominique Luton Jean-Christophe Richard Odile Launay Vassilis Tsatsaris François Goffinet Alexandre Mignon French Registry on 2009 A/H1N1v during pregnancy French experience of 2009 A/H1N1v influenza in pregnant women. |
| description |
<h4>Background</h4>The first reports on the pandemic influenza 2009 A/H1N1v from the USA, Mexico, and Australia indicated that this disease was associated with a high mortality in pregnant women. The aim of this study was to describe and compare the characteristics of severe critically ill and non-severe pregnant women with 2009 A/H1N1v-related illness in France.<h4>Methodology/principal findings</h4>A national registry was created to screen pregnant women with laboratory-confirmed 2009 A/H1N1v influenza. Three hundred and fifteen patients from 46 French hospitals were included: 40 patients were admitted to intensive care units (severe outcomes), 111 were hospitalized in obstetric or medical wards (moderate outcomes), and 164 were outpatients (mild outcomes). The 2009 A/H1N1v influenza illness occurred during all pregnancy trimesters, but most women (54%), notably the severe patients (70%), were in the third trimester. Among the severe patients, twenty (50%) underwent mechanical ventilation, and eleven (28%) were treated with extracorporeal membrane oxygenation. Three women died from A/H1N1v influenza. We found a strong association between the development of a severe outcome and both co-existing illnesses (adjusted odds ratio [OR], 5.1; 95% confidence interval [CI], 2.2-11.8) and a delay in oseltamivir treatment after the onset of symptoms (>3 or 5 days) (adjusted OR, 4.8; 95% CI, 1.9-12.1 and 61.2, 95% CI; 14.4-261.3, respectively). Among the 140 deliveries after 22 weeks of gestation known to date, 19 neonates (14%) were admitted to a neonatal intensive care unit, mainly for preterm delivery, and two neonates died. None of these neonates developed 2009 A/H1N1v infection.<h4>Conclusions</h4>This series confirms the high incidence of complications in pregnant women infected with pandemic A/H1N1v observed in other countries but depicts a lower overall maternal and neonatal mortality and morbidity than indicated in the USA or Australia. Moreover, our data demonstrate the benefit of early oseltamivir treatment in this specific population. |
| format |
article |
| author |
Grégory Dubar Elie Azria Antoine Tesnière Hervé Dupont Camille Le Ray Thomas Baugnon Sophie Matheron Dominique Luton Jean-Christophe Richard Odile Launay Vassilis Tsatsaris François Goffinet Alexandre Mignon French Registry on 2009 A/H1N1v during pregnancy |
| author_facet |
Grégory Dubar Elie Azria Antoine Tesnière Hervé Dupont Camille Le Ray Thomas Baugnon Sophie Matheron Dominique Luton Jean-Christophe Richard Odile Launay Vassilis Tsatsaris François Goffinet Alexandre Mignon French Registry on 2009 A/H1N1v during pregnancy |
| author_sort |
Grégory Dubar |
| title |
French experience of 2009 A/H1N1v influenza in pregnant women. |
| title_short |
French experience of 2009 A/H1N1v influenza in pregnant women. |
| title_full |
French experience of 2009 A/H1N1v influenza in pregnant women. |
| title_fullStr |
French experience of 2009 A/H1N1v influenza in pregnant women. |
| title_full_unstemmed |
French experience of 2009 A/H1N1v influenza in pregnant women. |
| title_sort |
french experience of 2009 a/h1n1v influenza in pregnant women. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/75a57b265c9c4811ab4081a5e087652e |
| work_keys_str_mv |
AT gregorydubar frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT elieazria frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT antoinetesniere frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT hervedupont frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT camilleleray frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT thomasbaugnon frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT sophiematheron frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT dominiqueluton frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT jeanchristopherichard frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT odilelaunay frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT vassilistsatsaris frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT francoisgoffinet frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT alexandremignon frenchexperienceof2009ah1n1vinfluenzainpregnantwomen AT frenchregistryon2009ah1n1vduringpregnancy frenchexperienceof2009ah1n1vinfluenzainpregnantwomen |
| _version_ |
1718423985466638336 |