Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

Abstract Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alterna...

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Autores principales:	Srinivasan Sanjay, Santosh Gopi Krishna Gadde, Sameeksha Agrawal, Padmamalini Mahendradas, Nivedhitha Govindaswamy, Ankush Kawali, Chaitra Jayadev, Sajjan Sangai, Abhijit Sinha Roy, Rohit Shetty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75a61befa4a04a65983c3e514ac1af34
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spelling	oai:doaj.org-article:75a61befa4a04a65983c3e514ac1af342021-12-02T19:10:21ZOptical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis10.1038/s41598-021-96715-82045-2322https://doaj.org/article/75a61befa4a04a65983c3e514ac1af342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96715-8https://doaj.org/toc/2045-2322Abstract Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence tomography (OCT) scans obtained. A qualitative and quantitative analysis was done for all images. 46 eyes of 33 patients were included in the study. Salient features noted were changes in the superficial (SCP) and deep capillary plexus (DCP) with capillary rarefaction and irregularity of larger vessels in the SCP. The DCP had more capillary rarefaction when compared to the SCP. The foveal avascular zone (FAZ) was altered with an irregular perifoveal network. Our series of post fever retinitis describes the salient vascular features on OCTA. Although the presumed aetiology was different in all our patients, they developed similar changes on OCTA. While OCTA is not useful if there is gross macular oedema, the altered FAZ can be indicative of macular ischemia.Srinivasan SanjaySantosh Gopi Krishna GaddeSameeksha AgrawalPadmamalini MahendradasNivedhitha GovindaswamyAnkush KawaliChaitra JayadevSajjan SangaiAbhijit Sinha RoyRohit ShettyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Srinivasan Sanjay Santosh Gopi Krishna Gadde Sameeksha Agrawal Padmamalini Mahendradas Nivedhitha Govindaswamy Ankush Kawali Chaitra Jayadev Sajjan Sangai Abhijit Sinha Roy Rohit Shetty Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
description	Abstract Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence tomography (OCT) scans obtained. A qualitative and quantitative analysis was done for all images. 46 eyes of 33 patients were included in the study. Salient features noted were changes in the superficial (SCP) and deep capillary plexus (DCP) with capillary rarefaction and irregularity of larger vessels in the SCP. The DCP had more capillary rarefaction when compared to the SCP. The foveal avascular zone (FAZ) was altered with an irregular perifoveal network. Our series of post fever retinitis describes the salient vascular features on OCTA. Although the presumed aetiology was different in all our patients, they developed similar changes on OCTA. While OCTA is not useful if there is gross macular oedema, the altered FAZ can be indicative of macular ischemia.
format	article
author	Srinivasan Sanjay Santosh Gopi Krishna Gadde Sameeksha Agrawal Padmamalini Mahendradas Nivedhitha Govindaswamy Ankush Kawali Chaitra Jayadev Sajjan Sangai Abhijit Sinha Roy Rohit Shetty
author_facet	Srinivasan Sanjay Santosh Gopi Krishna Gadde Sameeksha Agrawal Padmamalini Mahendradas Nivedhitha Govindaswamy Ankush Kawali Chaitra Jayadev Sajjan Sangai Abhijit Sinha Roy Rohit Shetty
author_sort	Srinivasan Sanjay
title	Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_short	Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_full	Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_fullStr	Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_full_unstemmed	Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_sort	optical coherence tomography angiography (octa) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/75a61befa4a04a65983c3e514ac1af34
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Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

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