Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination

Type 2 Diabetes Mellitus accounts for 90% of most diabetes cases. Many commercial drugs used to treat this disease come with adverse side effects and eventually fail to restore glucose homeostasis. Therefore, an effective, economical and safe antidiabetic remedy from dietary source is considered. Ta...

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Autores principales:	Nithiyaa Perumal, Meenakshii Nallappan, Shamarina Shohaimi, Nur Kartinee Kassim, Thiam Tsui Tee, Yew Hoong Cheah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Taraxacum officinale Momordica charantia Antidiabetes Dipeptidyl peptidase-4 (DPP-4) STZ-NA induced rat diabetic model LCMS Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/75abed3bc50c4680a33546ef81c46bfb
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spelling	oai:doaj.org-article:75abed3bc50c4680a33546ef81c46bfb2021-11-14T04:30:29ZSynergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination0753-332210.1016/j.biopha.2021.112401https://doaj.org/article/75abed3bc50c4680a33546ef81c46bfb2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011872https://doaj.org/toc/0753-3322Type 2 Diabetes Mellitus accounts for 90% of most diabetes cases. Many commercial drugs used to treat this disease come with adverse side effects and eventually fail to restore glucose homeostasis. Therefore, an effective, economical and safe antidiabetic remedy from dietary source is considered. Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. were chosen since both are used for centuries as traditional medicine to treat various ailments and diseases. In this study, the antidiabetic properties of a polyherbal combination of T. officinale and M. charantia ethanol extracts are evaluated. The bioactive solvent extracts of the samples selected from in vitro antidiabetic assays; α-amylase, α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) inhibition, and glucose-uptake in L6 muscle cells were combined (1:1) to form the polyherbal combination. The antidiabetic efficacy of polyherbal combination was evaluated employing the above stated in vitro antidiabetic assays and in vivo oral glucose tolerance test and streptozotocin-nicotinamide (STZ-NA) induced diabetic rat model. A quadrupole time-of-flight liquid chromatography-mass spectrometry (Q-TOF LCMS) analysis was done to identify active compounds. The polyherbal combination exerted improved antidiabetic properties; increased DPP-4, α-amylase, and α-glucosidase inhibition. The polyherbal combination tested in vivo on diabetic rats showed optimum blood glucose-lowering activity comparable to that of Glibenclamide and Metformin. This study confirms the polyherbal combination of T. officinale and M. charantia to be rich in various bioactive compounds, which exhibited antidiabetic properties. Therefore, this polyherbal combination has the potential to be further developed as complex phytotherapeutic remedy for the treatment of Type 2 Diabetes Mellitus.Nithiyaa PerumalMeenakshii NallappanShamarina ShohaimiNur Kartinee KassimThiam Tsui TeeYew Hoong CheahElsevierarticleTaraxacum officinaleMomordica charantiaAntidiabetesDipeptidyl peptidase-4 (DPP-4)STZ-NA induced rat diabetic modelLCMSTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112401- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Taraxacum officinale Momordica charantia Antidiabetes Dipeptidyl peptidase-4 (DPP-4) STZ-NA induced rat diabetic model LCMS Therapeutics. Pharmacology RM1-950
spellingShingle	Taraxacum officinale Momordica charantia Antidiabetes Dipeptidyl peptidase-4 (DPP-4) STZ-NA induced rat diabetic model LCMS Therapeutics. Pharmacology RM1-950 Nithiyaa Perumal Meenakshii Nallappan Shamarina Shohaimi Nur Kartinee Kassim Thiam Tsui Tee Yew Hoong Cheah Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
description	Type 2 Diabetes Mellitus accounts for 90% of most diabetes cases. Many commercial drugs used to treat this disease come with adverse side effects and eventually fail to restore glucose homeostasis. Therefore, an effective, economical and safe antidiabetic remedy from dietary source is considered. Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. were chosen since both are used for centuries as traditional medicine to treat various ailments and diseases. In this study, the antidiabetic properties of a polyherbal combination of T. officinale and M. charantia ethanol extracts are evaluated. The bioactive solvent extracts of the samples selected from in vitro antidiabetic assays; α-amylase, α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) inhibition, and glucose-uptake in L6 muscle cells were combined (1:1) to form the polyherbal combination. The antidiabetic efficacy of polyherbal combination was evaluated employing the above stated in vitro antidiabetic assays and in vivo oral glucose tolerance test and streptozotocin-nicotinamide (STZ-NA) induced diabetic rat model. A quadrupole time-of-flight liquid chromatography-mass spectrometry (Q-TOF LCMS) analysis was done to identify active compounds. The polyherbal combination exerted improved antidiabetic properties; increased DPP-4, α-amylase, and α-glucosidase inhibition. The polyherbal combination tested in vivo on diabetic rats showed optimum blood glucose-lowering activity comparable to that of Glibenclamide and Metformin. This study confirms the polyherbal combination of T. officinale and M. charantia to be rich in various bioactive compounds, which exhibited antidiabetic properties. Therefore, this polyherbal combination has the potential to be further developed as complex phytotherapeutic remedy for the treatment of Type 2 Diabetes Mellitus.
format	article
author	Nithiyaa Perumal Meenakshii Nallappan Shamarina Shohaimi Nur Kartinee Kassim Thiam Tsui Tee Yew Hoong Cheah
author_facet	Nithiyaa Perumal Meenakshii Nallappan Shamarina Shohaimi Nur Kartinee Kassim Thiam Tsui Tee Yew Hoong Cheah
author_sort	Nithiyaa Perumal
title	Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
title_short	Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
title_full	Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
title_fullStr	Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
title_full_unstemmed	Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination
title_sort	synergistic antidiabetic activity of taraxacum officinale (l.) weber ex f.h.wigg and momordica charantia l. polyherbal combination
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/75abed3bc50c4680a33546ef81c46bfb
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Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination

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