Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performe...
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2021
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oai:doaj.org-article:75ac65348b634c08883ab00b7735340a2021-11-25T16:56:51ZReaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder10.3390/brainsci111114222076-3425https://doaj.org/article/75ac65348b634c08883ab00b7735340a2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1422https://doaj.org/toc/2076-3425The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.Atiqul Haq MazumderJennifer BarnettErkki Tapio IsometsäNina LindbergMinna Torniainen-HolmMarkku LähteenvuoKaisla LahdensuoMartta KerkeläAri Ahola-OlliJarmo HietalaOlli KampmanTuula KieseppäTuomas JukuriKatja HäkkinenErik CederlöfWillehard HaakiRisto KajanneAsko WegeliusTeemu MännynsaloJussi Niemi-PynttäriKimmo SuokasJouko LönnqvistJari TiihonenTiina PaunioSeppo Juhani VainioAarno PalotieSolja NiemeläJaana SuvisaariJuha VeijolaMDPI AGarticlecognitionvisual memoryreaction timehazardous drinkingPGSschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1422, p 1422 (2021) |
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cognition visual memory reaction time hazardous drinking PGS schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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cognition visual memory reaction time hazardous drinking PGS schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Atiqul Haq Mazumder Jennifer Barnett Erkki Tapio Isometsä Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Ari Ahola-Olli Jarmo Hietala Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Jari Tiihonen Tiina Paunio Seppo Juhani Vainio Aarno Palotie Solja Niemelä Jaana Suvisaari Juha Veijola Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| description |
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. |
| format |
article |
| author |
Atiqul Haq Mazumder Jennifer Barnett Erkki Tapio Isometsä Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Ari Ahola-Olli Jarmo Hietala Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Jari Tiihonen Tiina Paunio Seppo Juhani Vainio Aarno Palotie Solja Niemelä Jaana Suvisaari Juha Veijola |
| author_facet |
Atiqul Haq Mazumder Jennifer Barnett Erkki Tapio Isometsä Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Ari Ahola-Olli Jarmo Hietala Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Jari Tiihonen Tiina Paunio Seppo Juhani Vainio Aarno Palotie Solja Niemelä Jaana Suvisaari Juha Veijola |
| author_sort |
Atiqul Haq Mazumder |
| title |
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| title_short |
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| title_full |
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| title_fullStr |
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| title_full_unstemmed |
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
| title_sort |
reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective disorder and bipolar disorder |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/75ac65348b634c08883ab00b7735340a |
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