Female mice are more prone to develop an addictive-like phenotype for sugar consumption

Abstract The concept of “sugar addiction” is gaining increasing attention in both the lay media and scientific literature. However, the concept of sugar addiction is controversial and only a few studies to date have attempted to determine the “addictive” properties of sugar using rigorous scientific...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shoupeng Wei, Sarah Hertle, Rainer Spanagel, Ainhoa Bilbao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75ad8a33d57843b59f0944d155ddaf97
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:75ad8a33d57843b59f0944d155ddaf97
record_format	dspace
spelling	oai:doaj.org-article:75ad8a33d57843b59f0944d155ddaf972021-12-02T14:25:03ZFemale mice are more prone to develop an addictive-like phenotype for sugar consumption10.1038/s41598-021-86797-92045-2322https://doaj.org/article/75ad8a33d57843b59f0944d155ddaf972021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86797-9https://doaj.org/toc/2045-2322Abstract The concept of “sugar addiction” is gaining increasing attention in both the lay media and scientific literature. However, the concept of sugar addiction is controversial and only a few studies to date have attempted to determine the “addictive” properties of sugar using rigorous scientific criteria. Here we set out to systematically test the addictive properties of sugar in male and female mice using established paradigms and models from the drug addiction field. Male and female C57BL/6N (8–10 weeks old) were evaluated in 4 experimental procedures to study the addictive properties of sugar: (i) a drinking in the dark (DID) procedure to model sugar binging; (ii) a long-term free choice home cage drinking procedure measuring the sugar deprivation effect (SDE) following an abstinence phase; (iii) a long-term operant sugar self-administration with persistence, motivation and compulsivity measures and (iv) intracranial self-stimulation (ICSS). Female mice were more vulnerable to the addictive properties of sugar than male mice, showing higher binge and long-term, excessive drinking, a more pronounced relapse-like drinking following deprivation, and higher persistence and motivation for sugar. No sex differences were seen in a compulsivity test or reward sensitivity measured using ICSS following extended sugar consumption. This study demonstrates the occurrence of an addictive-like phenotype for sugar in male and female mice, similar to drugs of abuse, and suggests sex-dependent differences in the development of sugar addiction.Shoupeng WeiSarah HertleRainer SpanagelAinhoa BilbaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shoupeng Wei Sarah Hertle Rainer Spanagel Ainhoa Bilbao Female mice are more prone to develop an addictive-like phenotype for sugar consumption
description	Abstract The concept of “sugar addiction” is gaining increasing attention in both the lay media and scientific literature. However, the concept of sugar addiction is controversial and only a few studies to date have attempted to determine the “addictive” properties of sugar using rigorous scientific criteria. Here we set out to systematically test the addictive properties of sugar in male and female mice using established paradigms and models from the drug addiction field. Male and female C57BL/6N (8–10 weeks old) were evaluated in 4 experimental procedures to study the addictive properties of sugar: (i) a drinking in the dark (DID) procedure to model sugar binging; (ii) a long-term free choice home cage drinking procedure measuring the sugar deprivation effect (SDE) following an abstinence phase; (iii) a long-term operant sugar self-administration with persistence, motivation and compulsivity measures and (iv) intracranial self-stimulation (ICSS). Female mice were more vulnerable to the addictive properties of sugar than male mice, showing higher binge and long-term, excessive drinking, a more pronounced relapse-like drinking following deprivation, and higher persistence and motivation for sugar. No sex differences were seen in a compulsivity test or reward sensitivity measured using ICSS following extended sugar consumption. This study demonstrates the occurrence of an addictive-like phenotype for sugar in male and female mice, similar to drugs of abuse, and suggests sex-dependent differences in the development of sugar addiction.
format	article
author	Shoupeng Wei Sarah Hertle Rainer Spanagel Ainhoa Bilbao
author_facet	Shoupeng Wei Sarah Hertle Rainer Spanagel Ainhoa Bilbao
author_sort	Shoupeng Wei
title	Female mice are more prone to develop an addictive-like phenotype for sugar consumption
title_short	Female mice are more prone to develop an addictive-like phenotype for sugar consumption
title_full	Female mice are more prone to develop an addictive-like phenotype for sugar consumption
title_fullStr	Female mice are more prone to develop an addictive-like phenotype for sugar consumption
title_full_unstemmed	Female mice are more prone to develop an addictive-like phenotype for sugar consumption
title_sort	female mice are more prone to develop an addictive-like phenotype for sugar consumption
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/75ad8a33d57843b59f0944d155ddaf97
work_keys_str_mv	AT shoupengwei femalemicearemorepronetodevelopanaddictivelikephenotypeforsugarconsumption AT sarahhertle femalemicearemorepronetodevelopanaddictivelikephenotypeforsugarconsumption AT rainerspanagel femalemicearemorepronetodevelopanaddictivelikephenotypeforsugarconsumption AT ainhoabilbao femalemicearemorepronetodevelopanaddictivelikephenotypeforsugarconsumption
_version_	1718391433539354624

Female mice are more prone to develop an addictive-like phenotype for sugar consumption

Ejemplares similares