The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons

Orhan Aydemir1, Peykan T&uuml;rk&ccedil;&uuml;oglu1, Yasemin Bulut2, Ahmet Kalkan31Firat University School of Medicine, Department of Ophthalmology, Elazig, Turkey; 2Firat University School of Medicine, Department of Microbiology, Elazig, Turkey; 3Firat University School of M...

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Autores principales:	Orhan Aydemir, Peykan T&uuml;rk&ccedil;&uuml;oglu, Yasemin Bulut, Ahmet Kalkan
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/75ada6de29054b08a8b06cbcf81d30fb
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spelling	oai:doaj.org-article:75ada6de29054b08a8b06cbcf81d30fb2021-12-02T04:28:42ZThe relationship of graft survival and herpes simplex virus latency in recipient corneal buttons1177-54671177-5483https://doaj.org/article/75ada6de29054b08a8b06cbcf81d30fb2007-10-01T00:00:00Zhttp://www.dovepress.com/the-relationship-of-graft-survival-and-herpes-simplex-virus-latency-in-a278https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Orhan Aydemir1, Peykan T&uuml;rk&ccedil;&uuml;oglu1, Yasemin Bulut2, Ahmet Kalkan31Firat University School of Medicine, Department of Ophthalmology, Elazig, Turkey; 2Firat University School of Medicine, Department of Microbiology, Elazig, Turkey; 3Firat University School of Medicine, Department of Infectious Diseases, Elazig, TurkeyPurpose: To demonstrate relationship between herpes simplex virus (HSV) corneal latency and graft survival.Methods: Prospective case control study. 28 recipient corneal buttons and donor cornea-scleral remnants were examined for HSV DNA with polymerase chain reaction (PCR). None of the recipient had a history of HSV infection. Serum samples of graft recipients were analyzed for the presence of anti-HSV IgG and IgM with enzyme-linked immunosorbent assay technique. All corneas were free of stromal scarring or epithelial defect before sampling and had an endothelial cell density of &gt;2000 cells/mm2.Results: In twenty three patients (82%) anti-HSV IgG was detected in serum. In none of the recipients anti-HSV IgM was positive. HSV DNA was positive in six out of twenty eight (21%) of the recipient corneal buttons and none of the donor cornea-scleral remnants. In eighteen months follow-up period three out of six (50%) HSV DNA positive and one out of twenty-two (4.5%) HSV DNA negative patients experienced late endothelial failure that was statistically significantly different (p = 0.022). Conclusion: Even without a history of HSV keratitis, presence of latent HSV virus in recipient cornea is an important risk factor for subsequent graft survival.Keywords: herpes simplex virus, polymerase chain reaction, corneal latency, corneal graft survival Orhan AydemirPeykan T&uuml;rk&ccedil;&uuml;ogluYasemin BulutAhmet KalkanDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2007, Iss Issue 2, Pp 127-131 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Orhan Aydemir Peykan T&uuml;rk&ccedil;&uuml;oglu Yasemin Bulut Ahmet Kalkan The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
description	Orhan Aydemir1, Peykan T&uuml;rk&ccedil;&uuml;oglu1, Yasemin Bulut2, Ahmet Kalkan31Firat University School of Medicine, Department of Ophthalmology, Elazig, Turkey; 2Firat University School of Medicine, Department of Microbiology, Elazig, Turkey; 3Firat University School of Medicine, Department of Infectious Diseases, Elazig, TurkeyPurpose: To demonstrate relationship between herpes simplex virus (HSV) corneal latency and graft survival.Methods: Prospective case control study. 28 recipient corneal buttons and donor cornea-scleral remnants were examined for HSV DNA with polymerase chain reaction (PCR). None of the recipient had a history of HSV infection. Serum samples of graft recipients were analyzed for the presence of anti-HSV IgG and IgM with enzyme-linked immunosorbent assay technique. All corneas were free of stromal scarring or epithelial defect before sampling and had an endothelial cell density of &gt;2000 cells/mm2.Results: In twenty three patients (82%) anti-HSV IgG was detected in serum. In none of the recipients anti-HSV IgM was positive. HSV DNA was positive in six out of twenty eight (21%) of the recipient corneal buttons and none of the donor cornea-scleral remnants. In eighteen months follow-up period three out of six (50%) HSV DNA positive and one out of twenty-two (4.5%) HSV DNA negative patients experienced late endothelial failure that was statistically significantly different (p = 0.022). Conclusion: Even without a history of HSV keratitis, presence of latent HSV virus in recipient cornea is an important risk factor for subsequent graft survival.Keywords: herpes simplex virus, polymerase chain reaction, corneal latency, corneal graft survival
format	article
author	Orhan Aydemir Peykan T&uuml;rk&ccedil;&uuml;oglu Yasemin Bulut Ahmet Kalkan
author_facet	Orhan Aydemir Peykan T&uuml;rk&ccedil;&uuml;oglu Yasemin Bulut Ahmet Kalkan
author_sort	Orhan Aydemir
title	The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
title_short	The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
title_full	The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
title_fullStr	The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
title_full_unstemmed	The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
title_sort	relationship of graft survival and herpes simplex virus latency in recipient corneal buttons
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/75ada6de29054b08a8b06cbcf81d30fb
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The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons

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