The transcriptional regulatory network of Mycobacterium tuberculosis.

Under the perspectives of network science and systems biology, the characterization of transcriptional regulatory (TR) networks beyond the context of model organisms offers a versatile tool whose potential remains yet mainly unexplored. In this work, we present an updated version of the TR network o...

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Autores principales:	Joaquín Sanz, Jorge Navarro, Ainhoa Arbués, Carlos Martín, Pedro C Marijuán, Yamir Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75adfa83ab1c4ce6ac531eb670fa5ac3
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id	oai:doaj.org-article:75adfa83ab1c4ce6ac531eb670fa5ac3
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spelling	oai:doaj.org-article:75adfa83ab1c4ce6ac531eb670fa5ac32021-11-18T06:49:56ZThe transcriptional regulatory network of Mycobacterium tuberculosis.1932-620310.1371/journal.pone.0022178https://doaj.org/article/75adfa83ab1c4ce6ac531eb670fa5ac32011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21818301/?tool=EBIhttps://doaj.org/toc/1932-6203Under the perspectives of network science and systems biology, the characterization of transcriptional regulatory (TR) networks beyond the context of model organisms offers a versatile tool whose potential remains yet mainly unexplored. In this work, we present an updated version of the TR network of Mycobacterium tuberculosis (M.tb), which incorporates newly characterized transcriptional regulations coming from 31 recent, different experimental works available in the literature. As a result of the incorporation of these data, the new network doubles the size of previous data collections, incorporating more than a third of the entire genome of the bacterium. We also present an exhaustive topological analysis of the new assembled network, focusing on the statistical characterization of motifs significances and the comparison with other model organisms. The expanded M.tb transcriptional regulatory network, considering its volume and completeness, constitutes an important resource for diverse tasks such as dynamic modeling of gene expression and signaling processes, computational reliability determination or protein function prediction, being the latter of particular relevance, given that the function of only a small percent of the proteins of M.tb is known.Joaquín SanzJorge NavarroAinhoa ArbuésCarlos MartínPedro C MarijuánYamir MorenoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22178 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joaquín Sanz Jorge Navarro Ainhoa Arbués Carlos Martín Pedro C Marijuán Yamir Moreno The transcriptional regulatory network of Mycobacterium tuberculosis.
description	Under the perspectives of network science and systems biology, the characterization of transcriptional regulatory (TR) networks beyond the context of model organisms offers a versatile tool whose potential remains yet mainly unexplored. In this work, we present an updated version of the TR network of Mycobacterium tuberculosis (M.tb), which incorporates newly characterized transcriptional regulations coming from 31 recent, different experimental works available in the literature. As a result of the incorporation of these data, the new network doubles the size of previous data collections, incorporating more than a third of the entire genome of the bacterium. We also present an exhaustive topological analysis of the new assembled network, focusing on the statistical characterization of motifs significances and the comparison with other model organisms. The expanded M.tb transcriptional regulatory network, considering its volume and completeness, constitutes an important resource for diverse tasks such as dynamic modeling of gene expression and signaling processes, computational reliability determination or protein function prediction, being the latter of particular relevance, given that the function of only a small percent of the proteins of M.tb is known.
format	article
author	Joaquín Sanz Jorge Navarro Ainhoa Arbués Carlos Martín Pedro C Marijuán Yamir Moreno
author_facet	Joaquín Sanz Jorge Navarro Ainhoa Arbués Carlos Martín Pedro C Marijuán Yamir Moreno
author_sort	Joaquín Sanz
title	The transcriptional regulatory network of Mycobacterium tuberculosis.
title_short	The transcriptional regulatory network of Mycobacterium tuberculosis.
title_full	The transcriptional regulatory network of Mycobacterium tuberculosis.
title_fullStr	The transcriptional regulatory network of Mycobacterium tuberculosis.
title_full_unstemmed	The transcriptional regulatory network of Mycobacterium tuberculosis.
title_sort	transcriptional regulatory network of mycobacterium tuberculosis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/75adfa83ab1c4ce6ac531eb670fa5ac3
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The transcriptional regulatory network of Mycobacterium tuberculosis.

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