The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Intu is a planar cell polarity protein known to regulate ciliogenesis during embryonic development. Here, Wang et al. identify a role for Intu in adult kidneys, where they find it promotes degradation of STAT1 and thus prevents cilia loss and cell death upon ischemia-reperfusion injury.

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Autores principales:	Shixuan Wang, Aimin Liu, Guangyu Wu, Han-Fei Ding, Shuang Huang, Stanley Nahman, Zheng Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/75afa4889d8245b9b9d38c61df9c7997
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spelling	oai:doaj.org-article:75afa4889d8245b9b9d38c61df9c79972021-12-02T14:38:50ZThe CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation10.1038/s41467-018-03628-82041-1723https://doaj.org/article/75afa4889d8245b9b9d38c61df9c79972018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03628-8https://doaj.org/toc/2041-1723Intu is a planar cell polarity protein known to regulate ciliogenesis during embryonic development. Here, Wang et al. identify a role for Intu in adult kidneys, where they find it promotes degradation of STAT1 and thus prevents cilia loss and cell death upon ischemia-reperfusion injury.Shixuan WangAimin LiuGuangyu WuHan-Fei DingShuang HuangStanley NahmanZheng DongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shixuan Wang Aimin Liu Guangyu Wu Han-Fei Ding Shuang Huang Stanley Nahman Zheng Dong The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
description	Intu is a planar cell polarity protein known to regulate ciliogenesis during embryonic development. Here, Wang et al. identify a role for Intu in adult kidneys, where they find it promotes degradation of STAT1 and thus prevents cilia loss and cell death upon ischemia-reperfusion injury.
format	article
author	Shixuan Wang Aimin Liu Guangyu Wu Han-Fei Ding Shuang Huang Stanley Nahman Zheng Dong
author_facet	Shixuan Wang Aimin Liu Guangyu Wu Han-Fei Ding Shuang Huang Stanley Nahman Zheng Dong
author_sort	Shixuan Wang
title	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
title_short	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
title_full	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
title_fullStr	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
title_full_unstemmed	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation
title_sort	cplane protein intu protects kidneys from ischemia-reperfusion injury by targeting stat1 for degradation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/75afa4889d8245b9b9d38c61df9c7997
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The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

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