Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention

Objective: To evaluate the efficacy and short term prognosis of Tirofiban in different treatment duration in patients with acute ST segment elevation myocardial infarction (STEMI) and percutaneous coronary intervention (PCI) combined with intracoronary injection. Methods: A total of 125 patients wit...

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Autores principales:	Zhen-Guo Ji, Hong-Bin Liu, Zhi-Hong Liu, Guo-Ping Ma, Li-Qiang Qin, Wei Dong, Li-Ya Wang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/75b2066d4dcb4a91b4ef5777097e16a2
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spelling	oai:doaj.org-article:75b2066d4dcb4a91b4ef5777097e16a22021-12-02T13:38:59ZInfluence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention2095-882X10.1016/j.cdtm.2015.06.003https://doaj.org/article/75b2066d4dcb4a91b4ef5777097e16a22015-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000341https://doaj.org/toc/2095-882XObjective: To evaluate the efficacy and short term prognosis of Tirofiban in different treatment duration in patients with acute ST segment elevation myocardial infarction (STEMI) and percutaneous coronary intervention (PCI) combined with intracoronary injection. Methods: A total of 125 patients with acute STEMI were enrolled in this study. They were randomly divided into two groups: control group (n = 61) and Tirofiban group (n = 64). The Tirofiban was used by intracoronary and intravenous administration in Tirofiban group which was randomly divided into three sub-groups according to the duration of Tirofiban by persistent intravenous injection for 12 hours, 24 hours or 36 hours. Thrombolysis in myocardial infarction flow and myocardial perfusion grades were recorded immediately after PCI. The adverse cardiac events and cardiac death within 180 days of PCI, and the adverse effects (hemorrhage and thrombocytopenia) were compared between the two groups and within Tirofiban sub-groups. Results: Grade 3 in myocardial perfusion was significantly better in Tirofiban group than control group (85.94% vs. 72.13%, P = 0.03) after PCI. There was one cardiac death in control group in 180 days after PCI. The adverse cardiac event rates between two groups was significant difference (16 patients in control group and only 8 in Tirofiban group, P = 0.047). There was no significant difference in incidence of hemorrhage complications and platelet counts between two groups. Nevertheless, hemorrhage complications in the 12- and 24-hour subgroups were less than 36-hour subgroup (P = 0.01). Conclusions: Intravenous Tirofiban treatment reduced the adverse cardiac events and improved short term prognosis without increasing the adverse reactions of the drugs in patients undergoing PCI. The less rate of hemorrhage complication can be achieved in short-duration of Tirofiban by intravenous injection after PCI. Keywords: Platelet glycoprotein IIb/IIIa inhibitor, Acute ST segment elevation myocardial infarction, Coronary artery, Percutaneous coronary interventionZhen-Guo JiHong-Bin LiuZhi-Hong LiuGuo-Ping MaLi-Qiang QinWei DongLi-Ya WangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 2, Pp 81-88 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhen-Guo Ji Hong-Bin Liu Zhi-Hong Liu Guo-Ping Ma Li-Qiang Qin Wei Dong Li-Ya Wang Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
description	Objective: To evaluate the efficacy and short term prognosis of Tirofiban in different treatment duration in patients with acute ST segment elevation myocardial infarction (STEMI) and percutaneous coronary intervention (PCI) combined with intracoronary injection. Methods: A total of 125 patients with acute STEMI were enrolled in this study. They were randomly divided into two groups: control group (n = 61) and Tirofiban group (n = 64). The Tirofiban was used by intracoronary and intravenous administration in Tirofiban group which was randomly divided into three sub-groups according to the duration of Tirofiban by persistent intravenous injection for 12 hours, 24 hours or 36 hours. Thrombolysis in myocardial infarction flow and myocardial perfusion grades were recorded immediately after PCI. The adverse cardiac events and cardiac death within 180 days of PCI, and the adverse effects (hemorrhage and thrombocytopenia) were compared between the two groups and within Tirofiban sub-groups. Results: Grade 3 in myocardial perfusion was significantly better in Tirofiban group than control group (85.94% vs. 72.13%, P = 0.03) after PCI. There was one cardiac death in control group in 180 days after PCI. The adverse cardiac event rates between two groups was significant difference (16 patients in control group and only 8 in Tirofiban group, P = 0.047). There was no significant difference in incidence of hemorrhage complications and platelet counts between two groups. Nevertheless, hemorrhage complications in the 12- and 24-hour subgroups were less than 36-hour subgroup (P = 0.01). Conclusions: Intravenous Tirofiban treatment reduced the adverse cardiac events and improved short term prognosis without increasing the adverse reactions of the drugs in patients undergoing PCI. The less rate of hemorrhage complication can be achieved in short-duration of Tirofiban by intravenous injection after PCI. Keywords: Platelet glycoprotein IIb/IIIa inhibitor, Acute ST segment elevation myocardial infarction, Coronary artery, Percutaneous coronary intervention
format	article
author	Zhen-Guo Ji Hong-Bin Liu Zhi-Hong Liu Guo-Ping Ma Li-Qiang Qin Wei Dong Li-Ya Wang
author_facet	Zhen-Guo Ji Hong-Bin Liu Zhi-Hong Liu Guo-Ping Ma Li-Qiang Qin Wei Dong Li-Ya Wang
author_sort	Zhen-Guo Ji
title	Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
title_short	Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
title_full	Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
title_fullStr	Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
title_full_unstemmed	Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
title_sort	influence of tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/75b2066d4dcb4a91b4ef5777097e16a2
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Influence of Tirofiban maintenance duration on patients with acute myocardial infarction treated by percutaneous coronary intervention

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