Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease

Abstract Background Although renal insufficiency and dyslipidemia are known to be closely associated, the effect of kidney function on the size and clinical value of high-density lipoprotein (HDL) particles remains largely unknown, especially in patients with coronary heart disease. Methods A total...

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Autores principales:	Long Jieni, Xue Yazhi, Zeng Xiaorong, Liu Dan, Ma Yusheng, Rao Jiahuan, Zhang Bin, Li Li, Guo Zhigang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Coronary heart disease Renal insufficiency HDL-C/apoA-I HDL particles Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/75b331ce781544b093d1acabce04a281
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spelling	oai:doaj.org-article:75b331ce781544b093d1acabce04a2812021-11-14T12:07:35ZEffect of renal function on high-density lipoprotein particles in patients with coronary heart disease10.1186/s12872-021-02354-21471-2261https://doaj.org/article/75b331ce781544b093d1acabce04a2812021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02354-2https://doaj.org/toc/1471-2261Abstract Background Although renal insufficiency and dyslipidemia are known to be closely associated, the effect of kidney function on the size and clinical value of high-density lipoprotein (HDL) particles remains largely unknown, especially in patients with coronary heart disease. Methods A total of 419 coronary heart disease patients and 105 non-coronary heart disease patients were included. HDL particle size, represented by HDL-C/apoA-I, was compared between groups stratified by estimated glomerular filtration rate (eGFR) and Gensini scores using standard Student’s t test and one-way ANOVA. Pearson’s correlation test was performed to analyze the association between eGFR and HDL-C/apoA-I in patients with coronary heart disease. The relationship between HDL particle size and the occurrence of coronary heart disease was explored using Univariate logistic regression analysis. Results In patients with coronary heart disease, between-group analysis revealed that HDL-C/apoA-I increased as eGFR declined, and significance appeared as eGFR declined to under 60 ml/min·1.73 m2 (P < 0.001), and Pearson's correlation test also confirmed an inverse correlation between eGFR and HDL-C/apoA-I levels in coronary heart disease patients. When stratified by Gensini scores, in coronary heart disease patients with eGFR ≥ 90 mL/(min·1.73 m2), those with higher Gensini scores had smaller HDL-C/apoA-I. However, with or without kidney insufficiency, smaller HDL-C/apoA-I was associated with a higher occurrence of coronary heart disease (P < 0.05). Conclusion With the presence of renal insufficiency, HDL-C/apoA1 was higher in patients with coronary heart disease. Lower HDL-C/apoA1 was still associated with a higher occurrence of coronary heart disease, but the original association between lower HDL-C/apoA1 and more severe coronary artery stenosis was lost in patients with renal insufficiency.Long JieniXue YazhiZeng XiaorongLiu DanMa YushengRao JiahuanZhang BinLi LiGuo ZhigangBMCarticleCoronary heart diseaseRenal insufficiencyHDL-C/apoA-IHDL particlesDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronary heart disease Renal insufficiency HDL-C/apoA-I HDL particles Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Coronary heart disease Renal insufficiency HDL-C/apoA-I HDL particles Diseases of the circulatory (Cardiovascular) system RC666-701 Long Jieni Xue Yazhi Zeng Xiaorong Liu Dan Ma Yusheng Rao Jiahuan Zhang Bin Li Li Guo Zhigang Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
description	Abstract Background Although renal insufficiency and dyslipidemia are known to be closely associated, the effect of kidney function on the size and clinical value of high-density lipoprotein (HDL) particles remains largely unknown, especially in patients with coronary heart disease. Methods A total of 419 coronary heart disease patients and 105 non-coronary heart disease patients were included. HDL particle size, represented by HDL-C/apoA-I, was compared between groups stratified by estimated glomerular filtration rate (eGFR) and Gensini scores using standard Student’s t test and one-way ANOVA. Pearson’s correlation test was performed to analyze the association between eGFR and HDL-C/apoA-I in patients with coronary heart disease. The relationship between HDL particle size and the occurrence of coronary heart disease was explored using Univariate logistic regression analysis. Results In patients with coronary heart disease, between-group analysis revealed that HDL-C/apoA-I increased as eGFR declined, and significance appeared as eGFR declined to under 60 ml/min·1.73 m2 (P < 0.001), and Pearson's correlation test also confirmed an inverse correlation between eGFR and HDL-C/apoA-I levels in coronary heart disease patients. When stratified by Gensini scores, in coronary heart disease patients with eGFR ≥ 90 mL/(min·1.73 m2), those with higher Gensini scores had smaller HDL-C/apoA-I. However, with or without kidney insufficiency, smaller HDL-C/apoA-I was associated with a higher occurrence of coronary heart disease (P < 0.05). Conclusion With the presence of renal insufficiency, HDL-C/apoA1 was higher in patients with coronary heart disease. Lower HDL-C/apoA1 was still associated with a higher occurrence of coronary heart disease, but the original association between lower HDL-C/apoA1 and more severe coronary artery stenosis was lost in patients with renal insufficiency.
format	article
author	Long Jieni Xue Yazhi Zeng Xiaorong Liu Dan Ma Yusheng Rao Jiahuan Zhang Bin Li Li Guo Zhigang
author_facet	Long Jieni Xue Yazhi Zeng Xiaorong Liu Dan Ma Yusheng Rao Jiahuan Zhang Bin Li Li Guo Zhigang
author_sort	Long Jieni
title	Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
title_short	Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
title_full	Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
title_fullStr	Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
title_full_unstemmed	Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
title_sort	effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/75b331ce781544b093d1acabce04a281
work_keys_str_mv	AT longjieni effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT xueyazhi effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT zengxiaorong effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT liudan effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT mayusheng effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT raojiahuan effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT zhangbin effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT lili effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease AT guozhigang effectofrenalfunctiononhighdensitylipoproteinparticlesinpatientswithcoronaryheartdisease
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Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease

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