Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

Guillaume Villatte,1,2 Christophe Massard,1 Stéphane Descamps,1,2 Yves Sibaud,1 Christiane Forestier,3 Komla-Oscar Awitor1 1Laboratory C-Biosenss EA 4676, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France; 2Department of Orthopedics, Clermo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Villatte G, Massard C, Descamps S, Sibaud Y, Forestier C, Awitor KO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/75ba92e41be94a0b90fee08047e39bd2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:75ba92e41be94a0b90fee08047e39bd2
record_format	dspace
spelling	oai:doaj.org-article:75ba92e41be94a0b90fee08047e39bd22021-12-02T04:33:04ZPhotoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application1178-2013https://doaj.org/article/75ba92e41be94a0b90fee08047e39bd22015-05-01T00:00:00Zhttp://www.dovepress.com/photoactive-tio2-antibacterial-coating-on-surgical-external-fixation-p-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Guillaume Villatte,1,2 Christophe Massard,1 Stéphane Descamps,1,2 Yves Sibaud,1 Christiane Forestier,3 Komla-Oscar Awitor1 1Laboratory C-Biosenss EA 4676, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France; 2Department of Orthopedics, Clermont-Ferrand University Hospital (CHU), Clermont-Ferrand, France; 3Laboratory Microorganism UMR 6023, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France Abstract: External fixation is a method of osteosynthesis currently used in traumatology and orthopedic surgery. Pin tract infection is a common problem in clinical practice. Infection occurs after bacterial colonization of the pin due to its contact with skin and the local environment. One way to prevent such local contamination is to create a specific coating that could be applied in the medical field. In this work, we developed a surface coating for external fixator pins based on the photocatalytic properties of titanium dioxide, producing a bactericidal effect with sufficient mechanical strength to be compatible with surgical use. The morphology and structure of the sol-gel coating layers were characterized using, respectively, scanning electron microscopy and X-ray diffraction. The resistance properties of the coating were investigated by mechanical testing. Photodegradation of acid orange 7 in aqueous solution was used as a probe to assess the photocatalytic activity of the titanium dioxide layers under ultraviolet irradiation. The bactericidal effect induced by the process was evaluated against two strains, ie, Staphylococcus aureus and multiresistant Staphylococcus epidermidis. The coated pins showed good mechanical strength and an efficient antibacterial effect after 1 hour of ultraviolet irradiation. Keywords: hybrid sol-gel, external pin fixation, titanium dioxide, antibacterial effect, mechanical strength, ultraviolet photoactivityVillatte GMassard CDescamps SSibaud YForestier CAwitor KODove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3367-3375 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Villatte G Massard C Descamps S Sibaud Y Forestier C Awitor KO Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
description	Guillaume Villatte,1,2 Christophe Massard,1 Stéphane Descamps,1,2 Yves Sibaud,1 Christiane Forestier,3 Komla-Oscar Awitor1 1Laboratory C-Biosenss EA 4676, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France; 2Department of Orthopedics, Clermont-Ferrand University Hospital (CHU), Clermont-Ferrand, France; 3Laboratory Microorganism UMR 6023, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France Abstract: External fixation is a method of osteosynthesis currently used in traumatology and orthopedic surgery. Pin tract infection is a common problem in clinical practice. Infection occurs after bacterial colonization of the pin due to its contact with skin and the local environment. One way to prevent such local contamination is to create a specific coating that could be applied in the medical field. In this work, we developed a surface coating for external fixator pins based on the photocatalytic properties of titanium dioxide, producing a bactericidal effect with sufficient mechanical strength to be compatible with surgical use. The morphology and structure of the sol-gel coating layers were characterized using, respectively, scanning electron microscopy and X-ray diffraction. The resistance properties of the coating were investigated by mechanical testing. Photodegradation of acid orange 7 in aqueous solution was used as a probe to assess the photocatalytic activity of the titanium dioxide layers under ultraviolet irradiation. The bactericidal effect induced by the process was evaluated against two strains, ie, Staphylococcus aureus and multiresistant Staphylococcus epidermidis. The coated pins showed good mechanical strength and an efficient antibacterial effect after 1 hour of ultraviolet irradiation. Keywords: hybrid sol-gel, external pin fixation, titanium dioxide, antibacterial effect, mechanical strength, ultraviolet photoactivity
format	article
author	Villatte G Massard C Descamps S Sibaud Y Forestier C Awitor KO
author_facet	Villatte G Massard C Descamps S Sibaud Y Forestier C Awitor KO
author_sort	Villatte G
title	Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
title_short	Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
title_full	Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
title_fullStr	Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
title_full_unstemmed	Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application
title_sort	photoactive tio2 antibacterial coating on surgical external fixation pins for clinical application
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/75ba92e41be94a0b90fee08047e39bd2
work_keys_str_mv	AT villatteg photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication AT massardc photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication AT descampss photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication AT sibaudy photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication AT forestierc photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication AT awitorko photoactivetio2antibacterialcoatingonsurgicalexternalfixationpinsforclinicalapplication
_version_	1718401192544960512

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

Ejemplares similares