Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.

It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function...

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Autores principales:	Dalia Sabra, Brittany Intzandt, Laurence Desjardins-Crepeau, Antoine Langeard, Christopher J Steele, Frédérique Frouin, Richard D Hoge, Louis Bherer, Claudine J Gauthier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75bcfad124234cfe9f84b6c088a992c7
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spelling	oai:doaj.org-article:75bcfad124234cfe9f84b6c088a992c72021-12-02T20:14:05ZSex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.1932-620310.1371/journal.pone.0257815https://doaj.org/article/75bcfad124234cfe9f84b6c088a992c72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257815https://doaj.org/toc/1932-6203It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship between AS and CVR is more complex, where some studies show decreased CVR with increased AS, and others demonstrate preserved CVR despite higher AS. Here, we investigated the possible role of sex on these hemodynamic relationships. Acquisitions were completed in 48 older adults. Pseudo-continuous arterial spin labeling (pCASL) data were collected during a hypercapnia challenge. Aortic pulse wave velocity (PWV) data was acquired using cine phase contrast velocity series. Cognitive function was assessed with a comprehensive neuropsychological battery, and a composite score for EF was calculated using four cognitive tests from the neuropsychological battery. A moderation model test revealed that sex moderated the relationship between PWV and CVR and PWV and EF, but not between CVR and EF. Together, our results indicate that the relationships between central stiffness, cerebral hemodynamics and cognition are in part mediated by sex.Dalia SabraBrittany IntzandtLaurence Desjardins-CrepeauAntoine LangeardChristopher J SteeleFrédérique FrouinRichard D HogeLouis BhererClaudine J GauthierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257815 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dalia Sabra Brittany Intzandt Laurence Desjardins-Crepeau Antoine Langeard Christopher J Steele Frédérique Frouin Richard D Hoge Louis Bherer Claudine J Gauthier Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
description	It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship between AS and CVR is more complex, where some studies show decreased CVR with increased AS, and others demonstrate preserved CVR despite higher AS. Here, we investigated the possible role of sex on these hemodynamic relationships. Acquisitions were completed in 48 older adults. Pseudo-continuous arterial spin labeling (pCASL) data were collected during a hypercapnia challenge. Aortic pulse wave velocity (PWV) data was acquired using cine phase contrast velocity series. Cognitive function was assessed with a comprehensive neuropsychological battery, and a composite score for EF was calculated using four cognitive tests from the neuropsychological battery. A moderation model test revealed that sex moderated the relationship between PWV and CVR and PWV and EF, but not between CVR and EF. Together, our results indicate that the relationships between central stiffness, cerebral hemodynamics and cognition are in part mediated by sex.
format	article
author	Dalia Sabra Brittany Intzandt Laurence Desjardins-Crepeau Antoine Langeard Christopher J Steele Frédérique Frouin Richard D Hoge Louis Bherer Claudine J Gauthier
author_facet	Dalia Sabra Brittany Intzandt Laurence Desjardins-Crepeau Antoine Langeard Christopher J Steele Frédérique Frouin Richard D Hoge Louis Bherer Claudine J Gauthier
author_sort	Dalia Sabra
title	Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
title_short	Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
title_full	Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
title_fullStr	Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
title_full_unstemmed	Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
title_sort	sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/75bcfad124234cfe9f84b6c088a992c7
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Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults.

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