Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium
Abstract Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syn...
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2017
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oai:doaj.org-article:75bd5f86d9964d35a798eed11e114f6f2021-12-02T11:52:27ZAltered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium10.1038/s41598-017-10024-72045-2322https://doaj.org/article/75bd5f86d9964d35a798eed11e114f6f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10024-7https://doaj.org/toc/2045-2322Abstract Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS. We found that the [oxy-Hb] change during the verbal fluency task (VFT) was reduced in patients with ESLD compared with healthy controls (HC) in the prefrontal and bi-temporal regions. The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions. Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex during SAT showed a positive correlation with the severity of delirium. Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained attention task measured with fNIRS might serve as a biological marker associated with delirium in ESLD patients.Atsushi YoshimuraCarrie GoodsonJordan T. JohnsMaxwell M. ToweEsme S. IrvineNada A. RendradjajaLaura K. MaxAndrew LaFlamEmily C. LedfordJulia ProbertZoë TiegesDavid H. EdwinAlasdair M. J. MacLullichCharles W. HogueMartin A. LindquistAhmet GurakarKarin J. NeufeldAtsushi KamiyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Atsushi Yoshimura Carrie Goodson Jordan T. Johns Maxwell M. Towe Esme S. Irvine Nada A. Rendradjaja Laura K. Max Andrew LaFlam Emily C. Ledford Julia Probert Zoë Tieges David H. Edwin Alasdair M. J. MacLullich Charles W. Hogue Martin A. Lindquist Ahmet Gurakar Karin J. Neufeld Atsushi Kamiya Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| description |
Abstract Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS. We found that the [oxy-Hb] change during the verbal fluency task (VFT) was reduced in patients with ESLD compared with healthy controls (HC) in the prefrontal and bi-temporal regions. The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions. Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex during SAT showed a positive correlation with the severity of delirium. Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained attention task measured with fNIRS might serve as a biological marker associated with delirium in ESLD patients. |
| format |
article |
| author |
Atsushi Yoshimura Carrie Goodson Jordan T. Johns Maxwell M. Towe Esme S. Irvine Nada A. Rendradjaja Laura K. Max Andrew LaFlam Emily C. Ledford Julia Probert Zoë Tieges David H. Edwin Alasdair M. J. MacLullich Charles W. Hogue Martin A. Lindquist Ahmet Gurakar Karin J. Neufeld Atsushi Kamiya |
| author_facet |
Atsushi Yoshimura Carrie Goodson Jordan T. Johns Maxwell M. Towe Esme S. Irvine Nada A. Rendradjaja Laura K. Max Andrew LaFlam Emily C. Ledford Julia Probert Zoë Tieges David H. Edwin Alasdair M. J. MacLullich Charles W. Hogue Martin A. Lindquist Ahmet Gurakar Karin J. Neufeld Atsushi Kamiya |
| author_sort |
Atsushi Yoshimura |
| title |
Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| title_short |
Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| title_full |
Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| title_fullStr |
Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| title_full_unstemmed |
Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium |
| title_sort |
altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: associations with delirium |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/75bd5f86d9964d35a798eed11e114f6f |
| work_keys_str_mv |
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