EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST

Pathogenesis of inflammatory bowel disease is complicated and multifactorial. T helper cells represent components of adaptive immune response, whereas Toll-like receptors, NOD-likereceptors, RIG-I-like receptors are involved in maintenance of mucosal, as well as commensal homeostasis. Aim of study w...

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Autores principales:	A. S. Zherebiatiev, A. M. Kamyshnyi, V. A. Kamyshnaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	experimental ileitis pattern recognition receptors il-1 receptor antagonist simvastatin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/75c175b603c14cd481f0bc9dcb3bda3f
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spelling	oai:doaj.org-article:75c175b603c14cd481f0bc9dcb3bda3f2021-11-18T08:03:44ZEXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST1563-06252313-741X10.15789/1563-0625-2015-2-119-126https://doaj.org/article/75c175b603c14cd481f0bc9dcb3bda3f2015-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/829https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPathogenesis of inflammatory bowel disease is complicated and multifactorial. T helper cells represent components of adaptive immune response, whereas Toll-like receptors, NOD-likereceptors, RIG-I-like receptors are involved in maintenance of mucosal, as well as commensal homeostasis. Aim of study was to evaluate the ability of Simvastatin and IL-1 receptor antagonist to modify the course of experimental ileitis in rats, with a focus on expression of TLR2, TLR4, NOD2, RIG-I, like as T-bet, GATA-3, RORγt, and FoxP3 transcription factors by resident lymphocytes in the small intestine. Experiments were carried out with male Wistar rats (5 to 7 months old). The immunopositive lymphocytes were determined by means of direct and indirect immunofluorescence technique, using monoclonal rat antibodies. Development of acute and chronic ileitis was associated with unidirectional tendency for increase of TLR2+ lymphocyte numbers, and decrease in total TLR4+ and FoxP3+ lymphocyte counts in lymphoid structures of ileum. Treatment of experimental animals with Simvastatin and ARIL-1 during the development of experimental pathology was accompanied by decrease of RORγt+ and T-bet+ lymphocytes, along with increasing total numbers of FoxP3+ lymphocytes. Simvastatin and antagonist of IL-1 receptors seem to exert a beneficial effect upon the course and outcomes in the indomethacin-induced rat ileitis model, via changing expression of pattern-recognizing receptors on lymphocytes and modulation of balance between different T helper cell subsets of intestinal tissues.A. S. ZherebiatievA. M. KamyshnyiV. A. KamyshnayaSPb RAACIarticleexperimental ileitispattern recognition receptorsil-1 receptor antagonistsimvastatinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 2, Pp 119-126 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	experimental ileitis pattern recognition receptors il-1 receptor antagonist simvastatin Immunologic diseases. Allergy RC581-607
spellingShingle	experimental ileitis pattern recognition receptors il-1 receptor antagonist simvastatin Immunologic diseases. Allergy RC581-607 A. S. Zherebiatiev A. M. Kamyshnyi V. A. Kamyshnaya EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
description	Pathogenesis of inflammatory bowel disease is complicated and multifactorial. T helper cells represent components of adaptive immune response, whereas Toll-like receptors, NOD-likereceptors, RIG-I-like receptors are involved in maintenance of mucosal, as well as commensal homeostasis. Aim of study was to evaluate the ability of Simvastatin and IL-1 receptor antagonist to modify the course of experimental ileitis in rats, with a focus on expression of TLR2, TLR4, NOD2, RIG-I, like as T-bet, GATA-3, RORγt, and FoxP3 transcription factors by resident lymphocytes in the small intestine. Experiments were carried out with male Wistar rats (5 to 7 months old). The immunopositive lymphocytes were determined by means of direct and indirect immunofluorescence technique, using monoclonal rat antibodies. Development of acute and chronic ileitis was associated with unidirectional tendency for increase of TLR2+ lymphocyte numbers, and decrease in total TLR4+ and FoxP3+ lymphocyte counts in lymphoid structures of ileum. Treatment of experimental animals with Simvastatin and ARIL-1 during the development of experimental pathology was accompanied by decrease of RORγt+ and T-bet+ lymphocytes, along with increasing total numbers of FoxP3+ lymphocytes. Simvastatin and antagonist of IL-1 receptors seem to exert a beneficial effect upon the course and outcomes in the indomethacin-induced rat ileitis model, via changing expression of pattern-recognizing receptors on lymphocytes and modulation of balance between different T helper cell subsets of intestinal tissues.
format	article
author	A. S. Zherebiatiev A. M. Kamyshnyi V. A. Kamyshnaya
author_facet	A. S. Zherebiatiev A. M. Kamyshnyi V. A. Kamyshnaya
author_sort	A. S. Zherebiatiev
title	EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
title_short	EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
title_full	EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
title_fullStr	EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
title_full_unstemmed	EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST
title_sort	expression of pattern-recognizing receptors and transcriptional regulators of t helper cell differentiation by intestinal lymphocytes in experimental ileitis and upon administration of simvastatin and interleukin-1 receptor antagonist
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/75c175b603c14cd481f0bc9dcb3bda3f
work_keys_str_mv	AT aszherebiatiev expressionofpatternrecognizingreceptorsandtranscriptionalregulatorsofthelpercelldifferentiationbyintestinallymphocytesinexperimentalileitisanduponadministrationofsimvastatinandinterleukin1receptorantagonist AT amkamyshnyi expressionofpatternrecognizingreceptorsandtranscriptionalregulatorsofthelpercelldifferentiationbyintestinallymphocytesinexperimentalileitisanduponadministrationofsimvastatinandinterleukin1receptorantagonist AT vakamyshnaya expressionofpatternrecognizingreceptorsandtranscriptionalregulatorsofthelpercelldifferentiationbyintestinallymphocytesinexperimentalileitisanduponadministrationofsimvastatinandinterleukin1receptorantagonist
_version_	1718422427050967040

EXPRESSION OF PATTERN-RECOGNIZING RECEPTORS AND TRANSCRIPTIONAL REGULATORS OF T HELPER CELL DIFFERENTIATION BY INTESTINAL LYMPHOCYTES IN EXPERIMENTAL ILEITIS AND UPON ADMINISTRATION OF SIMVASTATIN AND INTERLEUKIN-1 RECEPTOR ANTAGONIST

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