Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models

Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models

Abstract We have previously shown that the incomplete splicing of exon 1 to exon 2 of the HTT gene results in the production of a small polyadenylated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein. There is evidence to suggest that the splicing factor SRSF6 is involved...

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Autores principales: Michael A. Mason, Casandra Gomez-Paredes, Kirupa Sathasivam, Andreas Neueder, Aikaterini-Smaragdi Papadopoulou, Gillian P. Bates
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/75c2b3b27ebe45d08097db3813c6768f
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