Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects

Abstract Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogen...

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Autores principales:	Kyoung In Jung, Seon Joo Kim, Chan Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75c35726e0f946f9b84bd8fc6e3159aa
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spelling	oai:doaj.org-article:75c35726e0f946f9b84bd8fc6e3159aa2021-12-02T15:08:25ZSystemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects10.1038/s41598-018-26160-72045-2322https://doaj.org/article/75c35726e0f946f9b84bd8fc6e3159aa2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26160-7https://doaj.org/toc/2045-2322Abstract Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogenesis of various RNFL defect patterns. Data from subjects with multiple RNFL defects (28 patients) and glaucoma patients without multiple RNFL defects (194 patients) were analyzed. The term “multiple RNFL defects” refers to three or more isolated defects separated by a comparatively normal area. Patients with multiple RNFL defects showed a higher prevalence of hypertension, end-stage renal disease, and cerebrovascular disease than those without multiple RNFL defects, both before and after propensity score matching for age and mean deviation (all P < 0.05). The number of patients with parafoveal visual field points depressed <5% on pattern deviation plots was higher in subjects with multiple RNFL defects than in those without multiple RNFL defects (P = 0.048). In conclusion, the presence of multiple RNFL defects had clinical relevance for systemic vascular risk factors and a higher risk of parafoveal scotoma. Clinicians should be aware of the possibility of concomitant systemic vascular disease when evaluating patients with multiple RNFL defects.Kyoung In JungSeon Joo KimChan Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyoung In Jung Seon Joo Kim Chan Kee Park Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
description	Abstract Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogenesis of various RNFL defect patterns. Data from subjects with multiple RNFL defects (28 patients) and glaucoma patients without multiple RNFL defects (194 patients) were analyzed. The term “multiple RNFL defects” refers to three or more isolated defects separated by a comparatively normal area. Patients with multiple RNFL defects showed a higher prevalence of hypertension, end-stage renal disease, and cerebrovascular disease than those without multiple RNFL defects, both before and after propensity score matching for age and mean deviation (all P < 0.05). The number of patients with parafoveal visual field points depressed <5% on pattern deviation plots was higher in subjects with multiple RNFL defects than in those without multiple RNFL defects (P = 0.048). In conclusion, the presence of multiple RNFL defects had clinical relevance for systemic vascular risk factors and a higher risk of parafoveal scotoma. Clinicians should be aware of the possibility of concomitant systemic vascular disease when evaluating patients with multiple RNFL defects.
format	article
author	Kyoung In Jung Seon Joo Kim Chan Kee Park
author_facet	Kyoung In Jung Seon Joo Kim Chan Kee Park
author_sort	Kyoung In Jung
title	Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
title_short	Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
title_full	Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
title_fullStr	Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
title_full_unstemmed	Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects
title_sort	systemic vascular risk factors for multiple retinal nerve fiber layer defects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/75c35726e0f946f9b84bd8fc6e3159aa
work_keys_str_mv	AT kyounginjung systemicvascularriskfactorsformultipleretinalnervefiberlayerdefects AT seonjookim systemicvascularriskfactorsformultipleretinalnervefiberlayerdefects AT chankeepark systemicvascularriskfactorsformultipleretinalnervefiberlayerdefects
_version_	1718388128244301824

Systemic Vascular Risk Factors for Multiple Retinal Nerve Fiber Layer Defects

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