Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores

Introduction Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population da...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hugo Fontan Köhler, Genival Barbosa de Carvalho, Luiz Paulo Kowalski
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Revinter Publicações Ltda. 2021
Materias:	laryngeal neoplasms propensity score prognosis surgery radiotherapy Medicine R Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/75c416e95316413ba179f4bdcae33e5e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:75c416e95316413ba179f4bdcae33e5e
record_format	dspace
spelling	oai:doaj.org-article:75c416e95316413ba179f4bdcae33e5e2021-11-04T00:04:12ZTreatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores1809-97771809-486410.1055/s-0041-1726042https://doaj.org/article/75c416e95316413ba179f4bdcae33e5e2021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1726042https://doaj.org/toc/1809-9777https://doaj.org/toc/1809-4864Introduction Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population database. Methods A population database representing patients treated in the state of São Paulo, Brazil, was analyzed. Demographic, clinical and treatment variables were included, and the outcomes of interest were disease-specific and overall survival. Propensity score with nearest neighbor matching was used to compensate for imbalances in treatment groups. Results We retrieved data from 1,804 patients. In multivariate analysis, age, female gender, payment source, clinical N stage (cN) stages, and treatment modality were significant for disease-specific and overall survival. Patients submitted to surgery treatment had a significantly better disease-specific (p < 0.001) and overall survival (p < 0.001) compared with chemoradiation. Propensity score matching was based on cN stage, gender, age, topography, and payment modality, and allowed the pairing of 685 patients from each treatment modality. There was a significant difference in disease-specific survival favoring surgery-based treatment (p = 0.017). Conclusion The treatment choice has a significant impact on survival in patients with stage III laryngeal cancer with surgery-based treatment being superior to chemoradiotherapy (CRT).Hugo Fontan KöhlerGenival Barbosa de CarvalhoLuiz Paulo KowalskiThieme Revinter Publicações Ltda.articlelaryngeal neoplasmspropensity scoreprognosissurgeryradiotherapyMedicineROtorhinolaryngologyRF1-547ENInternational Archives of Otorhinolaryngology (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laryngeal neoplasms propensity score prognosis surgery radiotherapy Medicine R Otorhinolaryngology RF1-547
spellingShingle	laryngeal neoplasms propensity score prognosis surgery radiotherapy Medicine R Otorhinolaryngology RF1-547 Hugo Fontan Köhler Genival Barbosa de Carvalho Luiz Paulo Kowalski Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
description	Introduction Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population database. Methods A population database representing patients treated in the state of São Paulo, Brazil, was analyzed. Demographic, clinical and treatment variables were included, and the outcomes of interest were disease-specific and overall survival. Propensity score with nearest neighbor matching was used to compensate for imbalances in treatment groups. Results We retrieved data from 1,804 patients. In multivariate analysis, age, female gender, payment source, clinical N stage (cN) stages, and treatment modality were significant for disease-specific and overall survival. Patients submitted to surgery treatment had a significantly better disease-specific (p < 0.001) and overall survival (p < 0.001) compared with chemoradiation. Propensity score matching was based on cN stage, gender, age, topography, and payment modality, and allowed the pairing of 685 patients from each treatment modality. There was a significant difference in disease-specific survival favoring surgery-based treatment (p = 0.017). Conclusion The treatment choice has a significant impact on survival in patients with stage III laryngeal cancer with surgery-based treatment being superior to chemoradiotherapy (CRT).
format	article
author	Hugo Fontan Köhler Genival Barbosa de Carvalho Luiz Paulo Kowalski
author_facet	Hugo Fontan Köhler Genival Barbosa de Carvalho Luiz Paulo Kowalski
author_sort	Hugo Fontan Köhler
title	Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
title_short	Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
title_full	Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
title_fullStr	Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
title_full_unstemmed	Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
title_sort	treatment results for stage iii laryngeal cancer: analysis of a populational database using propensity scores
publisher	Thieme Revinter Publicações Ltda.
publishDate	2021
url	https://doaj.org/article/75c416e95316413ba179f4bdcae33e5e
work_keys_str_mv	AT hugofontankohler treatmentresultsforstageiiilaryngealcanceranalysisofapopulationaldatabaseusingpropensityscores AT genivalbarbosadecarvalho treatmentresultsforstageiiilaryngealcanceranalysisofapopulationaldatabaseusingpropensityscores AT luizpaulokowalski treatmentresultsforstageiiilaryngealcanceranalysisofapopulationaldatabaseusingpropensityscores
_version_	1718445337040912384

Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores

Ejemplares similares