TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection
Innate immune cells respond to a number of environmental cues including TLR signalling. Here the authors implicate mechanical sensor Piezo1 in the TLR4 mediated host response to bacterial infection and implicate it in the enhancement of macrophage mediated host response.
Saved in:
Main Authors: | Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/75c48bfb0aaf48df8cd5e8d33bcbb665 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
by: Ping Wang, et al.
Published: (2019) -
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
by: Hamza Atcha, et al.
Published: (2021) -
Voltage gating of mechanosensitive PIEZO channels
by: Mirko Moroni, et al.
Published: (2018) -
Piezo-catalysis for nondestructive tooth whitening
by: Yang Wang, et al.
Published: (2020) -
TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life.
by: Emma L Beckett, et al.
Published: (2012)