The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis
Tuberculosis is one of the most common infectious diseases and infectious causes of death worldwide. Over the last decades, significant research effort has been directed towards defining the understanding of the pathogenesis of tuberculosis to improve diagnosis and therapeutic options. Emerging scie...
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MDPI AG
2021
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oai:doaj.org-article:75d2290d7e7d4d9e89ab7a083061ba4a2021-11-25T17:52:08ZThe Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis10.3390/ijerph1822122201660-46011661-7827https://doaj.org/article/75d2290d7e7d4d9e89ab7a083061ba4a2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12220https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Tuberculosis is one of the most common infectious diseases and infectious causes of death worldwide. Over the last decades, significant research effort has been directed towards defining the understanding of the pathogenesis of tuberculosis to improve diagnosis and therapeutic options. Emerging scientific evidence indicates a possible role of the human microbiota in the pathophysiology of tuberculosis, response to therapy, clinical outcomes, and post-treatment outcomes. Although human studies on the role of the microbiota in tuberculosis are limited, published data in recent years, both from experimental and clinical studies, suggest that a better understanding of the gut–lung microbiome axis and microbiome–immune crosstalk could shed light on the specific pathogenetic mechanisms of <i>Mycobacterium tuberculosis</i> infection and identify new therapeutic targets. In this review, we address the current knowledge of the host immune responses against <i>Mycobacterium tuberculosis</i> infection, the emerging evidence on how gut and lung microbiota can modulate susceptibility to tuberculosis, the available studies on the possible use of probiotic–antibiotic combination therapy for the treatment of tuberculosis, and the knowledge gaps and future research priorities in this field.Pasquale ComberiatiMaria Di CiccoFrancesco ParavatiUmberto PelosiAlessandro Di GangiStefania ArasiSimona BarniDavide CaimmiCarla MastrorilliAmelia LicariFernanda ChieraMDPI AGarticlechildrengutinfectionlungmicrobiotamicrobiomeMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12220, p 12220 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
children gut infection lung microbiota microbiome Medicine R |
| spellingShingle |
children gut infection lung microbiota microbiome Medicine R Pasquale Comberiati Maria Di Cicco Francesco Paravati Umberto Pelosi Alessandro Di Gangi Stefania Arasi Simona Barni Davide Caimmi Carla Mastrorilli Amelia Licari Fernanda Chiera The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| description |
Tuberculosis is one of the most common infectious diseases and infectious causes of death worldwide. Over the last decades, significant research effort has been directed towards defining the understanding of the pathogenesis of tuberculosis to improve diagnosis and therapeutic options. Emerging scientific evidence indicates a possible role of the human microbiota in the pathophysiology of tuberculosis, response to therapy, clinical outcomes, and post-treatment outcomes. Although human studies on the role of the microbiota in tuberculosis are limited, published data in recent years, both from experimental and clinical studies, suggest that a better understanding of the gut–lung microbiome axis and microbiome–immune crosstalk could shed light on the specific pathogenetic mechanisms of <i>Mycobacterium tuberculosis</i> infection and identify new therapeutic targets. In this review, we address the current knowledge of the host immune responses against <i>Mycobacterium tuberculosis</i> infection, the emerging evidence on how gut and lung microbiota can modulate susceptibility to tuberculosis, the available studies on the possible use of probiotic–antibiotic combination therapy for the treatment of tuberculosis, and the knowledge gaps and future research priorities in this field. |
| format |
article |
| author |
Pasquale Comberiati Maria Di Cicco Francesco Paravati Umberto Pelosi Alessandro Di Gangi Stefania Arasi Simona Barni Davide Caimmi Carla Mastrorilli Amelia Licari Fernanda Chiera |
| author_facet |
Pasquale Comberiati Maria Di Cicco Francesco Paravati Umberto Pelosi Alessandro Di Gangi Stefania Arasi Simona Barni Davide Caimmi Carla Mastrorilli Amelia Licari Fernanda Chiera |
| author_sort |
Pasquale Comberiati |
| title |
The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| title_short |
The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| title_full |
The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| title_fullStr |
The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| title_full_unstemmed |
The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis |
| title_sort |
role of gut and lung microbiota in susceptibility to tuberculosis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/75d2290d7e7d4d9e89ab7a083061ba4a |
| work_keys_str_mv |
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1718411927881777152 |