Intracellular ATP Concentration and Implication for Cellular Evolution

Crystalline lens and striated muscle exist at opposite ends of the metabolic spectrum. Lens is a metabolically quiescent tissue, whereas striated muscle is a mechanically dynamic tissue with high-energy requirements, yet both tissues contain millimolar levels of ATP (>2.3 mM), far exceeding their...

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Autores principales:	Jack V. Greiner, Thomas Glonek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adenosine triphosphate ATP hydrotropic function interspecies protein aggregation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/75d2415190bc4d079dca42aedb91ce0e
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spelling	oai:doaj.org-article:75d2415190bc4d079dca42aedb91ce0e2021-11-25T16:47:37ZIntracellular ATP Concentration and Implication for Cellular Evolution10.3390/biology101111662079-7737https://doaj.org/article/75d2415190bc4d079dca42aedb91ce0e2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1166https://doaj.org/toc/2079-7737Crystalline lens and striated muscle exist at opposite ends of the metabolic spectrum. Lens is a metabolically quiescent tissue, whereas striated muscle is a mechanically dynamic tissue with high-energy requirements, yet both tissues contain millimolar levels of ATP (>2.3 mM), far exceeding their underlying metabolic needs. We explored intracellular concentrations of ATP across multiple cells, tissues, species, and domains to provide context for interpreting lens/striated muscle data. Our database revealed that high intracellular ATP concentrations are ubiquitous across diverse life forms including species existing from the Precambrian Era, suggesting an ancient highly conserved role for ATP, independent of its widely accepted view as primarily “metabolic currency”. Our findings reinforce suggestions that the primordial function of ATP was non-metabolic in nature, serving instead to prevent protein aggregation.Jack V. GreinerThomas GlonekMDPI AGarticleadenosine triphosphateATPhydrotropic functioninterspeciesprotein aggregationBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1166, p 1166 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenosine triphosphate ATP hydrotropic function interspecies protein aggregation Biology (General) QH301-705.5
spellingShingle	adenosine triphosphate ATP hydrotropic function interspecies protein aggregation Biology (General) QH301-705.5 Jack V. Greiner Thomas Glonek Intracellular ATP Concentration and Implication for Cellular Evolution
description	Crystalline lens and striated muscle exist at opposite ends of the metabolic spectrum. Lens is a metabolically quiescent tissue, whereas striated muscle is a mechanically dynamic tissue with high-energy requirements, yet both tissues contain millimolar levels of ATP (>2.3 mM), far exceeding their underlying metabolic needs. We explored intracellular concentrations of ATP across multiple cells, tissues, species, and domains to provide context for interpreting lens/striated muscle data. Our database revealed that high intracellular ATP concentrations are ubiquitous across diverse life forms including species existing from the Precambrian Era, suggesting an ancient highly conserved role for ATP, independent of its widely accepted view as primarily “metabolic currency”. Our findings reinforce suggestions that the primordial function of ATP was non-metabolic in nature, serving instead to prevent protein aggregation.
format	article
author	Jack V. Greiner Thomas Glonek
author_facet	Jack V. Greiner Thomas Glonek
author_sort	Jack V. Greiner
title	Intracellular ATP Concentration and Implication for Cellular Evolution
title_short	Intracellular ATP Concentration and Implication for Cellular Evolution
title_full	Intracellular ATP Concentration and Implication for Cellular Evolution
title_fullStr	Intracellular ATP Concentration and Implication for Cellular Evolution
title_full_unstemmed	Intracellular ATP Concentration and Implication for Cellular Evolution
title_sort	intracellular atp concentration and implication for cellular evolution
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/75d2415190bc4d079dca42aedb91ce0e
work_keys_str_mv	AT jackvgreiner intracellularatpconcentrationandimplicationforcellularevolution AT thomasglonek intracellularatpconcentrationandimplicationforcellularevolution
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Intracellular ATP Concentration and Implication for Cellular Evolution

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