Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

Abstract Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cel...

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Autores principales:	Xiuyun Xuan, Chunxia Tian, Mengjie Zhao, Yanhong Sun, Changzheng Huang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mesenchymal stem cells Cancer progression Therapeutic resistance Tumor microenvironment Cytokine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/75d421c59c244a3f8642bfd7e7ab0977
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spelling	oai:doaj.org-article:75d421c59c244a3f8642bfd7e7ab09772021-11-08T11:13:35ZMesenchymal stem cells in cancer progression and anticancer therapeutic resistance10.1186/s12935-021-02300-41475-2867https://doaj.org/article/75d421c59c244a3f8642bfd7e7ab09772021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02300-4https://doaj.org/toc/1475-2867Abstract Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.Xiuyun XuanChunxia TianMengjie ZhaoYanhong SunChangzheng HuangBMCarticleMesenchymal stem cellsCancer progressionTherapeutic resistanceTumor microenvironmentCytokineNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesenchymal stem cells Cancer progression Therapeutic resistance Tumor microenvironment Cytokine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Mesenchymal stem cells Cancer progression Therapeutic resistance Tumor microenvironment Cytokine Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Xiuyun Xuan Chunxia Tian Mengjie Zhao Yanhong Sun Changzheng Huang Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
description	Abstract Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.
format	article
author	Xiuyun Xuan Chunxia Tian Mengjie Zhao Yanhong Sun Changzheng Huang
author_facet	Xiuyun Xuan Chunxia Tian Mengjie Zhao Yanhong Sun Changzheng Huang
author_sort	Xiuyun Xuan
title	Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_short	Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_full	Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_fullStr	Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_full_unstemmed	Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_sort	mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
publisher	BMC
publishDate	2021
url	https://doaj.org/article/75d421c59c244a3f8642bfd7e7ab0977
work_keys_str_mv	AT xiuyunxuan mesenchymalstemcellsincancerprogressionandanticancertherapeuticresistance AT chunxiatian mesenchymalstemcellsincancerprogressionandanticancertherapeuticresistance AT mengjiezhao mesenchymalstemcellsincancerprogressionandanticancertherapeuticresistance AT yanhongsun mesenchymalstemcellsincancerprogressionandanticancertherapeuticresistance AT changzhenghuang mesenchymalstemcellsincancerprogressionandanticancertherapeuticresistance
_version_	1718442345321463808

Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

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