Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures
Bone mineral density (BMD) is the best predictor of osteoporotic fracture risk. Here, the authors perform a genome wide association study in Icelanders and people of European and East-Asian descent, and identify a new allele in intron 15 of the PTCH1gene that associates with reduced BMD.
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Nature Portfolio
2016
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oai:doaj.org-article:75d57f6551dd4b3da89bfcd9e832ac352021-12-02T15:35:44ZSequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures10.1038/ncomms101292041-1723https://doaj.org/article/75d57f6551dd4b3da89bfcd9e832ac352016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10129https://doaj.org/toc/2041-1723Bone mineral density (BMD) is the best predictor of osteoporotic fracture risk. Here, the authors perform a genome wide association study in Icelanders and people of European and East-Asian descent, and identify a new allele in intron 15 of the PTCH1gene that associates with reduced BMD.Unnur StyrkarsdottirGudmar ThorleifssonSigurjon A. GudjonssonAsgeir SigurdssonJacqueline R. CenterSeung Hun LeeTuan V. NguyenTimothy C.Y. KwokJenny S.W. LeeSuzanne C. HoJean WooPing-C. LeungBeom-Jun KimThorunn RafnarLambertus A. KiemeneyThorvaldur IngvarssonJung-Min KohNelson L.S. TangJohn A. EismanClaus ChristiansenGunnar SigurdssonUnnur ThorsteinsdottirKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016) |
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Science Q Unnur Styrkarsdottir Gudmar Thorleifsson Sigurjon A. Gudjonsson Asgeir Sigurdsson Jacqueline R. Center Seung Hun Lee Tuan V. Nguyen Timothy C.Y. Kwok Jenny S.W. Lee Suzanne C. Ho Jean Woo Ping-C. Leung Beom-Jun Kim Thorunn Rafnar Lambertus A. Kiemeney Thorvaldur Ingvarsson Jung-Min Koh Nelson L.S. Tang John A. Eisman Claus Christiansen Gunnar Sigurdsson Unnur Thorsteinsdottir Kari Stefansson Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| description |
Bone mineral density (BMD) is the best predictor of osteoporotic fracture risk. Here, the authors perform a genome wide association study in Icelanders and people of European and East-Asian descent, and identify a new allele in intron 15 of the PTCH1gene that associates with reduced BMD. |
| format |
article |
| author |
Unnur Styrkarsdottir Gudmar Thorleifsson Sigurjon A. Gudjonsson Asgeir Sigurdsson Jacqueline R. Center Seung Hun Lee Tuan V. Nguyen Timothy C.Y. Kwok Jenny S.W. Lee Suzanne C. Ho Jean Woo Ping-C. Leung Beom-Jun Kim Thorunn Rafnar Lambertus A. Kiemeney Thorvaldur Ingvarsson Jung-Min Koh Nelson L.S. Tang John A. Eisman Claus Christiansen Gunnar Sigurdsson Unnur Thorsteinsdottir Kari Stefansson |
| author_facet |
Unnur Styrkarsdottir Gudmar Thorleifsson Sigurjon A. Gudjonsson Asgeir Sigurdsson Jacqueline R. Center Seung Hun Lee Tuan V. Nguyen Timothy C.Y. Kwok Jenny S.W. Lee Suzanne C. Ho Jean Woo Ping-C. Leung Beom-Jun Kim Thorunn Rafnar Lambertus A. Kiemeney Thorvaldur Ingvarsson Jung-Min Koh Nelson L.S. Tang John A. Eisman Claus Christiansen Gunnar Sigurdsson Unnur Thorsteinsdottir Kari Stefansson |
| author_sort |
Unnur Styrkarsdottir |
| title |
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| title_short |
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| title_full |
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| title_fullStr |
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| title_full_unstemmed |
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures |
| title_sort |
sequence variants in the ptch1 gene associate with spine bone mineral density and osteoporotic fractures |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/75d57f6551dd4b3da89bfcd9e832ac35 |
| work_keys_str_mv |
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