Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures

Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures

Bone mineral density (BMD) is the best predictor of osteoporotic fracture risk. Here, the authors perform a genome wide association study in Icelanders and people of European and East-Asian descent, and identify a new allele in intron 15 of the PTCH1gene that associates with reduced BMD.

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Bibliographic Details
Main Authors: Unnur Styrkarsdottir, Gudmar Thorleifsson, Sigurjon A. Gudjonsson, Asgeir Sigurdsson, Jacqueline R. Center, Seung Hun Lee, Tuan V. Nguyen, Timothy C.Y. Kwok, Jenny S.W. Lee, Suzanne C. Ho, Jean Woo, Ping-C. Leung, Beom-Jun Kim, Thorunn Rafnar, Lambertus A. Kiemeney, Thorvaldur Ingvarsson, Jung-Min Koh, Nelson L.S. Tang, John A. Eisman, Claus Christiansen, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Kari Stefansson
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/75d57f6551dd4b3da89bfcd9e832ac35
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