Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes prolifera...

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Autores principales:	Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe, Eiji Hara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/75d7ca7f2bd04c92ac6d5b041481b7ec
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spelling	oai:doaj.org-article:75d7ca7f2bd04c92ac6d5b041481b7ec2021-12-02T15:38:55ZSmall extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA210.1038/ncomms157282041-1723https://doaj.org/article/75d7ca7f2bd04c92ac6d5b041481b7ec2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15728https://doaj.org/toc/2041-1723Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells.Masaki TakasugiRyo OkadaAkiko TakahashiDavid Virya ChenSugiko WatanabeEiji HaraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
description	Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells.
format	article
author	Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara
author_facet	Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara
author_sort	Masaki Takasugi
title	Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
title_short	Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
title_full	Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
title_fullStr	Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
title_full_unstemmed	Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
title_sort	small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through epha2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/75d7ca7f2bd04c92ac6d5b041481b7ec
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Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

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