Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study

Abstract Currently, it is unclear whether treating Helicobacter pylori (H. pylori) infection is safe among adolescents. This study aimed to evaluate the safety of H. pylori eradication therapy by examining gut microbiota changes in adolescents 3 months after the therapy. H. pylori-infected adolescen...

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Autores principales:	Toshihiko Kakiuchi, Kentaroh Yamamoto, Ichiro Imamura, Kazutoshi Hashiguchi, Hiroharu Kawakubo, Daisuke Yamaguchi, Yasuhiko Fujioka, Masumi Okuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75d8f83c458243aab8bfb0291485a529
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spelling	oai:doaj.org-article:75d8f83c458243aab8bfb0291485a5292021-12-02T14:01:22ZGut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study10.1038/s41598-020-80802-32045-2322https://doaj.org/article/75d8f83c458243aab8bfb0291485a5292021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80802-3https://doaj.org/toc/2045-2322Abstract Currently, it is unclear whether treating Helicobacter pylori (H. pylori) infection is safe among adolescents. This study aimed to evaluate the safety of H. pylori eradication therapy by examining gut microbiota changes in adolescents 3 months after the therapy. H. pylori-infected adolescents were enrolled in this study. Their stool samples were collected at the following three time points: before treatment, 1–2 days after completion of treatment, and time of eradication successful judgment. We assessed the relative abundance, alpha-diversity, and beta-diversity of the gut microbiota and adverse events. The number of isolated Actinobacteria decreased immediately after eradication therapy in the 16 students included in the study, and it returned to pretreatment condition at the eradication judgment point. There was no change in the relative abundance at genus level. The alpha-diversity was lost immediately after eradication therapy; however, it recovered at the time of eradication judgment, and it was restored to pretreatment condition. Meanwhile, none of the participants experienced serious adverse events. H. pylori eradication therapy is safe for adolescents with respect to gut microbiota changes associated with H. pylori eradication therapy. Therefore, further long-term evaluations of gut microbiota changes following eradication therapy are warranted.Toshihiko KakiuchiKentaroh YamamotoIchiro ImamuraKazutoshi HashiguchiHiroharu KawakuboDaisuke YamaguchiYasuhiko FujiokaMasumi OkudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshihiko Kakiuchi Kentaroh Yamamoto Ichiro Imamura Kazutoshi Hashiguchi Hiroharu Kawakubo Daisuke Yamaguchi Yasuhiko Fujioka Masumi Okuda Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
description	Abstract Currently, it is unclear whether treating Helicobacter pylori (H. pylori) infection is safe among adolescents. This study aimed to evaluate the safety of H. pylori eradication therapy by examining gut microbiota changes in adolescents 3 months after the therapy. H. pylori-infected adolescents were enrolled in this study. Their stool samples were collected at the following three time points: before treatment, 1–2 days after completion of treatment, and time of eradication successful judgment. We assessed the relative abundance, alpha-diversity, and beta-diversity of the gut microbiota and adverse events. The number of isolated Actinobacteria decreased immediately after eradication therapy in the 16 students included in the study, and it returned to pretreatment condition at the eradication judgment point. There was no change in the relative abundance at genus level. The alpha-diversity was lost immediately after eradication therapy; however, it recovered at the time of eradication judgment, and it was restored to pretreatment condition. Meanwhile, none of the participants experienced serious adverse events. H. pylori eradication therapy is safe for adolescents with respect to gut microbiota changes associated with H. pylori eradication therapy. Therefore, further long-term evaluations of gut microbiota changes following eradication therapy are warranted.
format	article
author	Toshihiko Kakiuchi Kentaroh Yamamoto Ichiro Imamura Kazutoshi Hashiguchi Hiroharu Kawakubo Daisuke Yamaguchi Yasuhiko Fujioka Masumi Okuda
author_facet	Toshihiko Kakiuchi Kentaroh Yamamoto Ichiro Imamura Kazutoshi Hashiguchi Hiroharu Kawakubo Daisuke Yamaguchi Yasuhiko Fujioka Masumi Okuda
author_sort	Toshihiko Kakiuchi
title	Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
title_short	Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
title_full	Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
title_fullStr	Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
title_full_unstemmed	Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
title_sort	gut microbiota changes related to helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/75d8f83c458243aab8bfb0291485a529
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Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study

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