Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues

The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human brea...

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Autores principales:	Wen-Jui Lee, Shih-Hsin Tu, Tzu-Chun Cheng, Juo-Han Lin, Ming-Thau Sheu, Ching-Chuan Kuo, Chun A. Changou, Chih-Hsiung Wu, Hui-Wen Chang, Hang-Lung Chang, Li-Ching Chen, Yuan-Soon Ho
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer tumor microenvironment hyaluronan synthase 3 tubulin acetylation autophagy Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/75da9fb660f848f9a5d1943f57c0c831
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id	oai:doaj.org-article:75da9fb660f848f9a5d1943f57c0c831
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spelling	oai:doaj.org-article:75da9fb660f848f9a5d1943f57c0c8312021-11-11T18:31:54ZType-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues10.3390/molecules262165481420-3049https://doaj.org/article/75da9fb660f848f9a5d1943f57c0c8312021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6548https://doaj.org/toc/1420-3049The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (PDX) experiments found that HA selected the highly migratory breast cancer cells with CD44 expression accumulated in the tumor/stroma junction. In conclusion, HAS3 and HA were detected in the stroma breast tissues at a high level attenuates effects for induced breast cancer cell death, and inhibit the cancer cells invasion at the initial stage. However, the highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.Wen-Jui LeeShih-Hsin TuTzu-Chun ChengJuo-Han LinMing-Thau SheuChing-Chuan KuoChun A. ChangouChih-Hsiung WuHui-Wen ChangHang-Lung ChangLi-Ching ChenYuan-Soon HoMDPI AGarticlebreast cancertumor microenvironmenthyaluronan synthase 3tubulin acetylationautophagyOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6548, p 6548 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer tumor microenvironment hyaluronan synthase 3 tubulin acetylation autophagy Organic chemistry QD241-441
spellingShingle	breast cancer tumor microenvironment hyaluronan synthase 3 tubulin acetylation autophagy Organic chemistry QD241-441 Wen-Jui Lee Shih-Hsin Tu Tzu-Chun Cheng Juo-Han Lin Ming-Thau Sheu Ching-Chuan Kuo Chun A. Changou Chih-Hsiung Wu Hui-Wen Chang Hang-Lung Chang Li-Ching Chen Yuan-Soon Ho Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
description	The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (PDX) experiments found that HA selected the highly migratory breast cancer cells with CD44 expression accumulated in the tumor/stroma junction. In conclusion, HAS3 and HA were detected in the stroma breast tissues at a high level attenuates effects for induced breast cancer cell death, and inhibit the cancer cells invasion at the initial stage. However, the highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.
format	article
author	Wen-Jui Lee Shih-Hsin Tu Tzu-Chun Cheng Juo-Han Lin Ming-Thau Sheu Ching-Chuan Kuo Chun A. Changou Chih-Hsiung Wu Hui-Wen Chang Hang-Lung Chang Li-Ching Chen Yuan-Soon Ho
author_facet	Wen-Jui Lee Shih-Hsin Tu Tzu-Chun Cheng Juo-Han Lin Ming-Thau Sheu Ching-Chuan Kuo Chun A. Changou Chih-Hsiung Wu Hui-Wen Chang Hang-Lung Chang Li-Ching Chen Yuan-Soon Ho
author_sort	Wen-Jui Lee
title	Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
title_short	Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
title_full	Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
title_fullStr	Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
title_full_unstemmed	Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues
title_sort	type-3 hyaluronan synthase attenuates tumor cells invasion in human mammary parenchymal tissues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/75da9fb660f848f9a5d1943f57c0c831
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Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues

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