NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic degradation via GABARAP interaction.

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Autores principales:	Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/75e721e981164b0eac18bb692e449bb8
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spelling	oai:doaj.org-article:75e721e981164b0eac18bb692e449bb82021-12-02T15:57:09ZNEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA10.1038/s41467-021-23599-72041-1723https://doaj.org/article/75e721e981164b0eac18bb692e449bb82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23599-7https://doaj.org/toc/2041-1723Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic degradation via GABARAP interaction.Yasuhiro YamamotoHaruka ChinoSatoshi TsukamotoKoji L. OdeHiroki R. UedaNoboru MizushimaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasuhiro Yamamoto Haruka Chino Satoshi Tsukamoto Koji L. Ode Hiroki R. Ueda Noboru Mizushima NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
description	Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic degradation via GABARAP interaction.
format	article
author	Yasuhiro Yamamoto Haruka Chino Satoshi Tsukamoto Koji L. Ode Hiroki R. Ueda Noboru Mizushima
author_facet	Yasuhiro Yamamoto Haruka Chino Satoshi Tsukamoto Koji L. Ode Hiroki R. Ueda Noboru Mizushima
author_sort	Yasuhiro Yamamoto
title	NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
title_short	NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
title_full	NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
title_fullStr	NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
title_full_unstemmed	NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
title_sort	nek9 regulates primary cilia formation by acting as a selective autophagy adaptor for myh9/myosin iia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/75e721e981164b0eac18bb692e449bb8
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NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

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