Endocytosis and exocytosis of nanoparticles in mammalian cells

Nuri Oh,1,2 Ji-Ho Park1–31Department of Bio and Brain Engineering, 2Institute for Optical Science and Technology, 3Institute for the NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaAbstract: Engineered nanoparticles that can be injected i...

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Autores principales:	Oh N, Park JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/75e8ba899b724d4fb8a2d68dc49e36ea
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spelling	oai:doaj.org-article:75e8ba899b724d4fb8a2d68dc49e36ea2021-12-02T07:13:44ZEndocytosis and exocytosis of nanoparticles in mammalian cells1178-2013https://doaj.org/article/75e8ba899b724d4fb8a2d68dc49e36ea2014-05-01T00:00:00Zhttp://www.dovepress.com/endocytosis-and-exocytosis-of-nanoparticles-in-mammalian-cells-a16697https://doaj.org/toc/1178-2013 Nuri Oh,1,2 Ji-Ho Park1–31Department of Bio and Brain Engineering, 2Institute for Optical Science and Technology, 3Institute for the NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaAbstract: Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues.Keywords: drug delivery, endocytosis, exocytosis, cancer cell, macrophage, nanoparticle, toxicityOh NPark JHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 1, Pp 51-63 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Oh N Park JH Endocytosis and exocytosis of nanoparticles in mammalian cells
description	Nuri Oh,1,2 Ji-Ho Park1–31Department of Bio and Brain Engineering, 2Institute for Optical Science and Technology, 3Institute for the NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaAbstract: Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues.Keywords: drug delivery, endocytosis, exocytosis, cancer cell, macrophage, nanoparticle, toxicity
format	article
author	Oh N Park JH
author_facet	Oh N Park JH
author_sort	Oh N
title	Endocytosis and exocytosis of nanoparticles in mammalian cells
title_short	Endocytosis and exocytosis of nanoparticles in mammalian cells
title_full	Endocytosis and exocytosis of nanoparticles in mammalian cells
title_fullStr	Endocytosis and exocytosis of nanoparticles in mammalian cells
title_full_unstemmed	Endocytosis and exocytosis of nanoparticles in mammalian cells
title_sort	endocytosis and exocytosis of nanoparticles in mammalian cells
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/75e8ba899b724d4fb8a2d68dc49e36ea
work_keys_str_mv	AT ohn endocytosisandexocytosisofnanoparticlesinmammaliancells AT parkjh endocytosisandexocytosisofnanoparticlesinmammaliancells
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Endocytosis and exocytosis of nanoparticles in mammalian cells

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