Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.

<h4>Background</h4>Sydenham chorea (SC), a neuropsychiatric sequela of group-A streptococcal infection, is associated with basal ganglia autoantibodies. Although autoantibodies have been proposed in neuropsychiatric disorders, little evidence has been shown to link autoimmunity and clini...

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Autores principales:	Hilla Ben-Pazi, Julie A Stoner, Madeleine W Cunningham
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75ec9393150d4ca08df8d8a99255463a
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spelling	oai:doaj.org-article:75ec9393150d4ca08df8d8a99255463a2021-11-18T08:54:26ZDopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.1932-620310.1371/journal.pone.0073516https://doaj.org/article/75ec9393150d4ca08df8d8a99255463a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24073196/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Sydenham chorea (SC), a neuropsychiatric sequela of group-A streptococcal infection, is associated with basal ganglia autoantibodies. Although autoantibodies have been proposed in neuropsychiatric disorders, little evidence has been shown to link autoimmunity and clinical symptoms. We hypothesized that dopamine receptor-autoantibody interactions may be the basis of neuropsychiatric symptoms in SC.<h4>Methods</h4>Sera from 22 children with SC (age 10.7±4.5 years) and 22 age-matched controls were studied. Clinical neuropsychiatric symptoms were measured in SC at sample collection using the UFMG-Sydenham's-Chorea-Rating-Scale (USCRS). Anti-dopamine D1 receptor (D1R) and anti-dopamine D2 receptor (D2R) autoantibodies were measured by the enzyme linked immunosorbent assay (ELISA) and were correlated with clinical symptoms.<h4>Results</h4>Anti-D1R and anti-D2R autoantibodies were significantly higher in SC compared to controls (n = 44; p = 0.010 and p = 0.017, respectively). We found that the ratio (anti-D2R/D1R) of the two anti-dopaminergic receptor antibodies correlated with neuropsychiatric symptoms as determined by USCRS measurements (n = 18; r = 0.53, p = 0.024). In addition, anti-D2R titers correlated with antistreptolysin-O titers (n = 43; r = 0.49, p = 0.0008).<h4>Interpretation</h4>Our report linked, for the first time, autoimmunity with neuropsychiatric symptoms. The significant correlation was found using ratios of autoantibodies against dopamine receptors (anti-D2R/D1R) rather than the absolute elevated individual anti-D1R or anti-D2R titers. We suggest that autoantibodies may lead to a receptor imbalance and induce greater sensitivity to dopamine signaling potentially leading to neuropsychiatric symptoms in SC. Our novel findings suggesting altered balance in the dopaminergic system may provide a new approach in understanding autoimmune neuropsychiatric disorders with possible implications for diagnosis and treatment.Hilla Ben-PaziJulie A StonerMadeleine W CunninghamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73516 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hilla Ben-Pazi Julie A Stoner Madeleine W Cunningham Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
description	<h4>Background</h4>Sydenham chorea (SC), a neuropsychiatric sequela of group-A streptococcal infection, is associated with basal ganglia autoantibodies. Although autoantibodies have been proposed in neuropsychiatric disorders, little evidence has been shown to link autoimmunity and clinical symptoms. We hypothesized that dopamine receptor-autoantibody interactions may be the basis of neuropsychiatric symptoms in SC.<h4>Methods</h4>Sera from 22 children with SC (age 10.7±4.5 years) and 22 age-matched controls were studied. Clinical neuropsychiatric symptoms were measured in SC at sample collection using the UFMG-Sydenham's-Chorea-Rating-Scale (USCRS). Anti-dopamine D1 receptor (D1R) and anti-dopamine D2 receptor (D2R) autoantibodies were measured by the enzyme linked immunosorbent assay (ELISA) and were correlated with clinical symptoms.<h4>Results</h4>Anti-D1R and anti-D2R autoantibodies were significantly higher in SC compared to controls (n = 44; p = 0.010 and p = 0.017, respectively). We found that the ratio (anti-D2R/D1R) of the two anti-dopaminergic receptor antibodies correlated with neuropsychiatric symptoms as determined by USCRS measurements (n = 18; r = 0.53, p = 0.024). In addition, anti-D2R titers correlated with antistreptolysin-O titers (n = 43; r = 0.49, p = 0.0008).<h4>Interpretation</h4>Our report linked, for the first time, autoimmunity with neuropsychiatric symptoms. The significant correlation was found using ratios of autoantibodies against dopamine receptors (anti-D2R/D1R) rather than the absolute elevated individual anti-D1R or anti-D2R titers. We suggest that autoantibodies may lead to a receptor imbalance and induce greater sensitivity to dopamine signaling potentially leading to neuropsychiatric symptoms in SC. Our novel findings suggesting altered balance in the dopaminergic system may provide a new approach in understanding autoimmune neuropsychiatric disorders with possible implications for diagnosis and treatment.
format	article
author	Hilla Ben-Pazi Julie A Stoner Madeleine W Cunningham
author_facet	Hilla Ben-Pazi Julie A Stoner Madeleine W Cunningham
author_sort	Hilla Ben-Pazi
title	Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
title_short	Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
title_full	Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
title_fullStr	Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
title_full_unstemmed	Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.
title_sort	dopamine receptor autoantibodies correlate with symptoms in sydenham's chorea.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/75ec9393150d4ca08df8d8a99255463a
work_keys_str_mv	AT hillabenpazi dopaminereceptorautoantibodiescorrelatewithsymptomsinsydenhamschorea AT julieastoner dopaminereceptorautoantibodiescorrelatewithsymptomsinsydenhamschorea AT madeleinewcunningham dopaminereceptorautoantibodiescorrelatewithsymptomsinsydenhamschorea
_version_	1718421208961122304

Dopamine receptor autoantibodies correlate with symptoms in Sydenham's chorea.

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