Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.

Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human patients infected with malaria parasites, aty...

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Autores principales:	Juan Rivera-Correa, Joseph Verdi, Julian Sherman, Jeremy M Sternberg, Jayne Raper, Ana Rodriguez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/75eca697b21141c1ba78895455e9cb51
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spelling	oai:doaj.org-article:75eca697b21141c1ba78895455e9cb512021-12-02T20:24:01ZAutoimmunity to phosphatidylserine and anemia in African Trypanosome infections.1935-27271935-273510.1371/journal.pntd.0009814https://doaj.org/article/75eca697b21141c1ba78895455e9cb512021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009814https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human patients infected with malaria parasites, atypical B-cells promote anemia through the secretion of autoimmune anti-phosphatidylserine (anti-PS) antibodies that bind to uninfected erythrocytes and facilitate their clearance. Using mouse models of two trypanosome infections, Trypanosoma brucei and Trypanosoma cruzi, we assessed levels of autoantibodies and anemia. Our results indicate that acute T. brucei infection, but not T. cruzi, leads to early increased levels of plasma autoantibodies against different auto antigens tested (PS, DNA and erythrocyte lysate) and expansion of atypical B cells (ABCs) that secrete these autoantibodies. In vitro studies confirmed that a lysate of T. brucei, but not T. cruzi, could directly promote the expansion of these ABCs. PS exposure on erythrocyte plasma membrane seems to be an important contributor to anemia by delaying erythrocyte recovery since treatment with an agent that prevents binding to it (Annexin V) ameliorated anemia in T. brucei-infected mice. Analysis of the plasma of patients with human African trypanosomiasis (HAT) revealed high levels of anti-PS antibodies that correlated with anemia. Altogether these results suggest a relation between autoimmunity against PS and anemia in both mice and patients infected with T. brucei.Juan Rivera-CorreaJoseph VerdiJulian ShermanJeremy M SternbergJayne RaperAna RodriguezPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009814 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Juan Rivera-Correa Joseph Verdi Julian Sherman Jeremy M Sternberg Jayne Raper Ana Rodriguez Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
description	Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human patients infected with malaria parasites, atypical B-cells promote anemia through the secretion of autoimmune anti-phosphatidylserine (anti-PS) antibodies that bind to uninfected erythrocytes and facilitate their clearance. Using mouse models of two trypanosome infections, Trypanosoma brucei and Trypanosoma cruzi, we assessed levels of autoantibodies and anemia. Our results indicate that acute T. brucei infection, but not T. cruzi, leads to early increased levels of plasma autoantibodies against different auto antigens tested (PS, DNA and erythrocyte lysate) and expansion of atypical B cells (ABCs) that secrete these autoantibodies. In vitro studies confirmed that a lysate of T. brucei, but not T. cruzi, could directly promote the expansion of these ABCs. PS exposure on erythrocyte plasma membrane seems to be an important contributor to anemia by delaying erythrocyte recovery since treatment with an agent that prevents binding to it (Annexin V) ameliorated anemia in T. brucei-infected mice. Analysis of the plasma of patients with human African trypanosomiasis (HAT) revealed high levels of anti-PS antibodies that correlated with anemia. Altogether these results suggest a relation between autoimmunity against PS and anemia in both mice and patients infected with T. brucei.
format	article
author	Juan Rivera-Correa Joseph Verdi Julian Sherman Jeremy M Sternberg Jayne Raper Ana Rodriguez
author_facet	Juan Rivera-Correa Joseph Verdi Julian Sherman Jeremy M Sternberg Jayne Raper Ana Rodriguez
author_sort	Juan Rivera-Correa
title	Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
title_short	Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
title_full	Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
title_fullStr	Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
title_full_unstemmed	Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
title_sort	autoimmunity to phosphatidylserine and anemia in african trypanosome infections.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/75eca697b21141c1ba78895455e9cb51
work_keys_str_mv	AT juanriveracorrea autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections AT josephverdi autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections AT juliansherman autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections AT jeremymsternberg autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections AT jayneraper autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections AT anarodriguez autoimmunitytophosphatidylserineandanemiainafricantrypanosomeinfections
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Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.

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