Pathways shaping the mitochondrial inner membrane

Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These includ...

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Autores principales:	Till Klecker, Benedikt Westermann
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	ATP synthase cristae Mgm1 MICOS mitochondrial lipids Saccharomyces cerevisiae Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/75ecfe2df5b849dc9bd84ff4db1fee07
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spelling	oai:doaj.org-article:75ecfe2df5b849dc9bd84ff4db1fee072021-12-01T08:06:05ZPathways shaping the mitochondrial inner membrane10.1098/rsob.2102382046-2441https://doaj.org/article/75ecfe2df5b849dc9bd84ff4db1fee072021-12-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsob.210238https://doaj.org/toc/2046-2441Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These include dimer formation of the mitochondrial ATP synthase, assembly of the mitochondrial contact site and cristae organizing system (MICOS), inner membrane remodelling by a dynamin-related GTPase (Mgm1/OPA1), and modulation of the mitochondrial lipid composition. In this review, we describe the function of the evolutionarily conserved machineries involved in mitochondrial cristae biogenesis with a focus on yeast and present current models to explain how their coordinated activities establish mitochondrial membrane architecture.Till KleckerBenedikt WestermannThe Royal SocietyarticleATP synthasecristaeMgm1MICOSmitochondrial lipidsSaccharomyces cerevisiaeBiology (General)QH301-705.5ENOpen Biology, Vol 11, Iss 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ATP synthase cristae Mgm1 MICOS mitochondrial lipids Saccharomyces cerevisiae Biology (General) QH301-705.5
spellingShingle	ATP synthase cristae Mgm1 MICOS mitochondrial lipids Saccharomyces cerevisiae Biology (General) QH301-705.5 Till Klecker Benedikt Westermann Pathways shaping the mitochondrial inner membrane
description	Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These include dimer formation of the mitochondrial ATP synthase, assembly of the mitochondrial contact site and cristae organizing system (MICOS), inner membrane remodelling by a dynamin-related GTPase (Mgm1/OPA1), and modulation of the mitochondrial lipid composition. In this review, we describe the function of the evolutionarily conserved machineries involved in mitochondrial cristae biogenesis with a focus on yeast and present current models to explain how their coordinated activities establish mitochondrial membrane architecture.
format	article
author	Till Klecker Benedikt Westermann
author_facet	Till Klecker Benedikt Westermann
author_sort	Till Klecker
title	Pathways shaping the mitochondrial inner membrane
title_short	Pathways shaping the mitochondrial inner membrane
title_full	Pathways shaping the mitochondrial inner membrane
title_fullStr	Pathways shaping the mitochondrial inner membrane
title_full_unstemmed	Pathways shaping the mitochondrial inner membrane
title_sort	pathways shaping the mitochondrial inner membrane
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/75ecfe2df5b849dc9bd84ff4db1fee07
work_keys_str_mv	AT tillklecker pathwaysshapingthemitochondrialinnermembrane AT benediktwestermann pathwaysshapingthemitochondrialinnermembrane
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Pathways shaping the mitochondrial inner membrane

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