Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures

Objective: This study aimed to determine the effect of reperfusion therapies on the occurrence of early post-stroke seizures (PSS) in patients with acute ischemic stroke (AIS).Background: Reperfusion therapies are paramount to the treatment of stroke in the acute phase. However, their effect on the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tasnim Mushannen, Rozaleen Aleyadeh, Maria Siddiqui, Maher Saqqur, Naveed Akhtar, Boulenouar Mesraoua, Salman Al Jerdi, Gayane Melikyan, Yanal Shaheen, Haneen Qadourah, Odette Chagoury, Ziyad R. Mahfoud, Naim Haddad
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	reperfusion therapies stroke early post-stroke seizures thrombolysis mechanical thrombectomy symptomatic seizures Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/75f83d24b9e1434db9a8783ff294c359
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:75f83d24b9e1434db9a8783ff294c359
record_format	dspace
spelling	oai:doaj.org-article:75f83d24b9e1434db9a8783ff294c3592021-11-22T04:28:39ZEffect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures1664-229510.3389/fneur.2021.758181https://doaj.org/article/75f83d24b9e1434db9a8783ff294c3592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.758181/fullhttps://doaj.org/toc/1664-2295Objective: This study aimed to determine the effect of reperfusion therapies on the occurrence of early post-stroke seizures (PSS) in patients with acute ischemic stroke (AIS).Background: Reperfusion therapies are paramount to the treatment of stroke in the acute phase. However, their effect on the incidence of early seizures after an AIS remains unclear.Design and Methods: The stroke database at Hamad Medical Corporation was used to identify all patients who received reperfusion therapies for AIS from 2016 to 2019. They were matched with patients of similar diagnosis, gender, age, and stroke severity as measured by National Institutes of Health Stroke Scale (NIHSS) who did not receive such treatment. The rates of early PSS were calculated for each group.Results: The results showed that 508 patients received reperfusion therapies (342 had IV thrombolysis only, 70 had thrombectomies only, and 96 had received both), compared with 501 matched patients receiving standard stroke unit care. Patients who received reperfusion therapies were similar to their matched controls for mean admission NIHSS score (9.87 vs. 9.79; p = 0.831), mean age (53.3 vs. 53.2 years; p = 0.849), and gender distribution (85 vs. 86% men; p = 0.655). The group receiving reperfusion therapies was found to have increased stroke cortical involvement (62 vs. 49.3%, p < 0.001) and hemorrhagic transformation rates (33.5 vs. 18.6%, p < 0.001) compared with the control group. The rate of early PSS was significantly lower in patients who received reperfusion therapies compared with those who did not (3.1 vs. 5.8%, respectively; p = 0.042). When we excluded seizures occurring at stroke onset prior to any potential treatment implementation, the difference in early PSS rates between the two groups was no longer significant (2.6 vs. 3.9%, respectively; p = 0.251). There was no significant difference in early PSS rate based on the type of reperfusion therapy either (3.2% with thrombolysis, 2.9% with thrombectomy, and 3.1% for the combined treatment, p = 0.309).Conclusions: Treatment of AIS with either thrombectomy, thrombolysis, or both does not increase the risk of early PSS.Tasnim MushannenRozaleen AleyadehMaria SiddiquiMaher SaqqurMaher SaqqurNaveed AkhtarBoulenouar MesraouaBoulenouar MesraouaSalman Al JerdiSalman Al JerdiGayane MelikyanGayane MelikyanYanal ShaheenHaneen QadourahOdette ChagouryOdette ChagouryZiyad R. MahfoudNaim HaddadNaim HaddadFrontiers Media S.A.articlereperfusion therapiesstrokeearly post-stroke seizuresthrombolysismechanical thrombectomysymptomatic seizuresNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reperfusion therapies stroke early post-stroke seizures thrombolysis mechanical thrombectomy symptomatic seizures Neurology. Diseases of the nervous system RC346-429
spellingShingle	reperfusion therapies stroke early post-stroke seizures thrombolysis mechanical thrombectomy symptomatic seizures Neurology. Diseases of the nervous system RC346-429 Tasnim Mushannen Rozaleen Aleyadeh Maria Siddiqui Maher Saqqur Maher Saqqur Naveed Akhtar Boulenouar Mesraoua Boulenouar Mesraoua Salman Al Jerdi Salman Al Jerdi Gayane Melikyan Gayane Melikyan Yanal Shaheen Haneen Qadourah Odette Chagoury Odette Chagoury Ziyad R. Mahfoud Naim Haddad Naim Haddad Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
description	Objective: This study aimed to determine the effect of reperfusion therapies on the occurrence of early post-stroke seizures (PSS) in patients with acute ischemic stroke (AIS).Background: Reperfusion therapies are paramount to the treatment of stroke in the acute phase. However, their effect on the incidence of early seizures after an AIS remains unclear.Design and Methods: The stroke database at Hamad Medical Corporation was used to identify all patients who received reperfusion therapies for AIS from 2016 to 2019. They were matched with patients of similar diagnosis, gender, age, and stroke severity as measured by National Institutes of Health Stroke Scale (NIHSS) who did not receive such treatment. The rates of early PSS were calculated for each group.Results: The results showed that 508 patients received reperfusion therapies (342 had IV thrombolysis only, 70 had thrombectomies only, and 96 had received both), compared with 501 matched patients receiving standard stroke unit care. Patients who received reperfusion therapies were similar to their matched controls for mean admission NIHSS score (9.87 vs. 9.79; p = 0.831), mean age (53.3 vs. 53.2 years; p = 0.849), and gender distribution (85 vs. 86% men; p = 0.655). The group receiving reperfusion therapies was found to have increased stroke cortical involvement (62 vs. 49.3%, p < 0.001) and hemorrhagic transformation rates (33.5 vs. 18.6%, p < 0.001) compared with the control group. The rate of early PSS was significantly lower in patients who received reperfusion therapies compared with those who did not (3.1 vs. 5.8%, respectively; p = 0.042). When we excluded seizures occurring at stroke onset prior to any potential treatment implementation, the difference in early PSS rates between the two groups was no longer significant (2.6 vs. 3.9%, respectively; p = 0.251). There was no significant difference in early PSS rate based on the type of reperfusion therapy either (3.2% with thrombolysis, 2.9% with thrombectomy, and 3.1% for the combined treatment, p = 0.309).Conclusions: Treatment of AIS with either thrombectomy, thrombolysis, or both does not increase the risk of early PSS.
format	article
author	Tasnim Mushannen Rozaleen Aleyadeh Maria Siddiqui Maher Saqqur Maher Saqqur Naveed Akhtar Boulenouar Mesraoua Boulenouar Mesraoua Salman Al Jerdi Salman Al Jerdi Gayane Melikyan Gayane Melikyan Yanal Shaheen Haneen Qadourah Odette Chagoury Odette Chagoury Ziyad R. Mahfoud Naim Haddad Naim Haddad
author_facet	Tasnim Mushannen Rozaleen Aleyadeh Maria Siddiqui Maher Saqqur Maher Saqqur Naveed Akhtar Boulenouar Mesraoua Boulenouar Mesraoua Salman Al Jerdi Salman Al Jerdi Gayane Melikyan Gayane Melikyan Yanal Shaheen Haneen Qadourah Odette Chagoury Odette Chagoury Ziyad R. Mahfoud Naim Haddad Naim Haddad
author_sort	Tasnim Mushannen
title	Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
title_short	Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
title_full	Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
title_fullStr	Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
title_full_unstemmed	Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures
title_sort	effect of reperfusion therapies on incidence of early post-stroke seizures
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/75f83d24b9e1434db9a8783ff294c359
work_keys_str_mv	AT tasnimmushannen effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT rozaleenaleyadeh effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT mariasiddiqui effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT mahersaqqur effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT mahersaqqur effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT naveedakhtar effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT boulenouarmesraoua effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT boulenouarmesraoua effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT salmanaljerdi effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT salmanaljerdi effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT gayanemelikyan effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT gayanemelikyan effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT yanalshaheen effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT haneenqadourah effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT odettechagoury effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT odettechagoury effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT ziyadrmahfoud effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT naimhaddad effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures AT naimhaddad effectofreperfusiontherapiesonincidenceofearlypoststrokeseizures
_version_	1718418168005787648

Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures

Ejemplares similares