Expanding the drug discovery space with predicted metabolite–target interactions

Using computational approaches, Nuzzo et al. identify 983 potential metabolite–human target interactions from the Inflammatory Bowel Disease (IBD) cohort dataset of the Human Microbiome Project 2 (HMP2) and public databases. These predicted interactions can further the understanding of host–microbio...

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Bibliographic Details
Main Authors: Andrea Nuzzo, Somdutta Saha, Ellen Berg, Channa Jayawickreme, Joel Tocker, James R. Brown
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/75f87b3c80b74ee3b132d5f3e4bd2ef1
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Summary:Using computational approaches, Nuzzo et al. identify 983 potential metabolite–human target interactions from the Inflammatory Bowel Disease (IBD) cohort dataset of the Human Microbiome Project 2 (HMP2) and public databases. These predicted interactions can further the understanding of host–microbiome interactions and assist in drug discovery for IBD and other diseases.