Exposome in human health: Utopia or wonderland?
Summary: The current human exposome primarily emphasizes the total environmental exposure during an entire life. The characteristics of “lifelong” and “all environmental factors” make it very challenging to bring the exposomic study into real-life applications. Herein, we mainly discuss the typical...
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Elsevier
2021
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oai:doaj.org-article:75f987bd8c0042e99f9fc29a72dd18952021-11-28T04:39:14ZExposome in human health: Utopia or wonderland?2666-675810.1016/j.xinn.2021.100172https://doaj.org/article/75f987bd8c0042e99f9fc29a72dd18952021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666675821000977https://doaj.org/toc/2666-6758Summary: The current human exposome primarily emphasizes the total environmental exposure during an entire life. The characteristics of “lifelong” and “all environmental factors” make it very challenging to bring the exposomic study into real-life applications. Herein, we mainly discuss the typical application scenarios of exposomics and how to conduct an exposomic study to establish relationships between the exposome and human health. To increase the feasibility and efficiency, we propose that (1) an exposomic study can start with health events during critical-window periods; (2) both data- and hypothesis-driven exposomics should be combined to prioritize the risk of environmental factors; and (3) reliable statistical analysis of high-dimensional data of external and internal exposure factors are urgently needed. With standardization of the exposomic study, it will be critical to build a “wonderland” for human health.Mingliang FangLigang HuDa ChenYuming GuoJianmeng LiuChangxin LanJicheng GongBin WangElsevierarticleexposomeexposomicshealth risk assessmenthuman healthcritical windowScience (General)Q1-390ENThe Innovation, Vol 2, Iss 4, Pp 100172- (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
exposome exposomics health risk assessment human health critical window Science (General) Q1-390 |
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exposome exposomics health risk assessment human health critical window Science (General) Q1-390 Mingliang Fang Ligang Hu Da Chen Yuming Guo Jianmeng Liu Changxin Lan Jicheng Gong Bin Wang Exposome in human health: Utopia or wonderland? |
| description |
Summary: The current human exposome primarily emphasizes the total environmental exposure during an entire life. The characteristics of “lifelong” and “all environmental factors” make it very challenging to bring the exposomic study into real-life applications. Herein, we mainly discuss the typical application scenarios of exposomics and how to conduct an exposomic study to establish relationships between the exposome and human health. To increase the feasibility and efficiency, we propose that (1) an exposomic study can start with health events during critical-window periods; (2) both data- and hypothesis-driven exposomics should be combined to prioritize the risk of environmental factors; and (3) reliable statistical analysis of high-dimensional data of external and internal exposure factors are urgently needed. With standardization of the exposomic study, it will be critical to build a “wonderland” for human health. |
| format |
article |
| author |
Mingliang Fang Ligang Hu Da Chen Yuming Guo Jianmeng Liu Changxin Lan Jicheng Gong Bin Wang |
| author_facet |
Mingliang Fang Ligang Hu Da Chen Yuming Guo Jianmeng Liu Changxin Lan Jicheng Gong Bin Wang |
| author_sort |
Mingliang Fang |
| title |
Exposome in human health: Utopia or wonderland? |
| title_short |
Exposome in human health: Utopia or wonderland? |
| title_full |
Exposome in human health: Utopia or wonderland? |
| title_fullStr |
Exposome in human health: Utopia or wonderland? |
| title_full_unstemmed |
Exposome in human health: Utopia or wonderland? |
| title_sort |
exposome in human health: utopia or wonderland? |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/75f987bd8c0042e99f9fc29a72dd1895 |
| work_keys_str_mv |
AT mingliangfang exposomeinhumanhealthutopiaorwonderland AT liganghu exposomeinhumanhealthutopiaorwonderland AT dachen exposomeinhumanhealthutopiaorwonderland AT yumingguo exposomeinhumanhealthutopiaorwonderland AT jianmengliu exposomeinhumanhealthutopiaorwonderland AT changxinlan exposomeinhumanhealthutopiaorwonderland AT jichenggong exposomeinhumanhealthutopiaorwonderland AT binwang exposomeinhumanhealthutopiaorwonderland |
| _version_ |
1718408267343855616 |