Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.

<h4>Objectives</h4>Recent neuroimaging studies have identified a potentially critical role of the amygdala in disrupted emotion neurocircuitry in individuals after total sleep deprivation (TSD). However, connectivity between the amygdala and cerebral cortex due to TSD remains to be eluci...

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Autores principales:	Yongcong Shao, Yu Lei, Lubin Wang, Tianye Zhai, Xiao Jin, Wei Ni, Yue Yang, Shuwen Tan, Bo Wen, Enmao Ye, Zheng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75fa37ee68f04482a67c2767c3ca9ec7
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spelling	oai:doaj.org-article:75fa37ee68f04482a67c2767c3ca9ec72021-11-25T05:54:32ZAltered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.1932-620310.1371/journal.pone.0112222https://doaj.org/article/75fa37ee68f04482a67c2767c3ca9ec72014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0112222https://doaj.org/toc/1932-6203<h4>Objectives</h4>Recent neuroimaging studies have identified a potentially critical role of the amygdala in disrupted emotion neurocircuitry in individuals after total sleep deprivation (TSD). However, connectivity between the amygdala and cerebral cortex due to TSD remains to be elucidated. In this study, we used resting-state functional MRI (fMRI) to investigate the functional connectivity changes of the basolateral amygdala (BLA) and centromedial amygdala (CMA) in the brain after 36 h of TSD.<h4>Materials and methods</h4>Fourteen healthy adult men aged 25.9 ± 2.3 years (range, 18-28 years) were enrolled in a within-subject crossover study. Using the BLA and CMA as separate seed regions, we examined resting-state functional connectivity with fMRI during rested wakefulness (RW) and after 36 h of TSD.<h4>Results</h4>TSD resulted in a significant decrease in the functional connectivity between the BLA and several executive control regions (left dorsolateral prefrontal cortex [DLPFC], right dorsal anterior cingulate cortex [ACC], right inferior frontal gyrus [IFG]). Increased functional connectivity was found between the BLA and areas including the left posterior cingulate cortex/precuneus (PCC/PrCu) and right parahippocampal gyrus. With regard to CMA, increased functional connectivity was observed with the rostral anterior cingulate cortex (rACC) and right precentral gyrus.<h4>Conclusion</h4>These findings demonstrate that disturbance in amygdala related circuits may contribute to TSD psychophysiology and suggest that functional connectivity studies of the amygdala during the resting state may be used to discern aberrant patterns of coupling within these circuits after TSD.Yongcong ShaoYu LeiLubin WangTianye ZhaiXiao JinWei NiYue YangShuwen TanBo WenEnmao YeZheng YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e112222 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongcong Shao Yu Lei Lubin Wang Tianye Zhai Xiao Jin Wei Ni Yue Yang Shuwen Tan Bo Wen Enmao Ye Zheng Yang Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
description	<h4>Objectives</h4>Recent neuroimaging studies have identified a potentially critical role of the amygdala in disrupted emotion neurocircuitry in individuals after total sleep deprivation (TSD). However, connectivity between the amygdala and cerebral cortex due to TSD remains to be elucidated. In this study, we used resting-state functional MRI (fMRI) to investigate the functional connectivity changes of the basolateral amygdala (BLA) and centromedial amygdala (CMA) in the brain after 36 h of TSD.<h4>Materials and methods</h4>Fourteen healthy adult men aged 25.9 ± 2.3 years (range, 18-28 years) were enrolled in a within-subject crossover study. Using the BLA and CMA as separate seed regions, we examined resting-state functional connectivity with fMRI during rested wakefulness (RW) and after 36 h of TSD.<h4>Results</h4>TSD resulted in a significant decrease in the functional connectivity between the BLA and several executive control regions (left dorsolateral prefrontal cortex [DLPFC], right dorsal anterior cingulate cortex [ACC], right inferior frontal gyrus [IFG]). Increased functional connectivity was found between the BLA and areas including the left posterior cingulate cortex/precuneus (PCC/PrCu) and right parahippocampal gyrus. With regard to CMA, increased functional connectivity was observed with the rostral anterior cingulate cortex (rACC) and right precentral gyrus.<h4>Conclusion</h4>These findings demonstrate that disturbance in amygdala related circuits may contribute to TSD psychophysiology and suggest that functional connectivity studies of the amygdala during the resting state may be used to discern aberrant patterns of coupling within these circuits after TSD.
format	article
author	Yongcong Shao Yu Lei Lubin Wang Tianye Zhai Xiao Jin Wei Ni Yue Yang Shuwen Tan Bo Wen Enmao Ye Zheng Yang
author_facet	Yongcong Shao Yu Lei Lubin Wang Tianye Zhai Xiao Jin Wei Ni Yue Yang Shuwen Tan Bo Wen Enmao Ye Zheng Yang
author_sort	Yongcong Shao
title	Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
title_short	Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
title_full	Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
title_fullStr	Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
title_full_unstemmed	Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
title_sort	altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/75fa37ee68f04482a67c2767c3ca9ec7
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Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.

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