Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Influenza A virus (IAV) causes annual epidemics and development of antivirals is needed. Here, the authors perform phosphoproteomics during IAV entry and identify GRK2 as drug target, inhibition of which decreases replication of seasonal and pandemic IAV in primary human cells and animal models.

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Detalles Bibliográficos
Autores principales: Emilio Yángüez, Annika Hunziker, Maria Pamela Dobay, Soner Yildiz, Simon Schading, Elizaveta Elshina, Umut Karakus, Peter Gehrig, Jonas Grossmann, Ronald Dijkman, Mirco Schmolke, Silke Stertz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/75fc5e0fffec45b99c4b42c17dc10447
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