Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission

Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission

The GABARAP protein is known to support the stability of GABAA receptors (GABAARs) in synapses, but the underlying molecular mechanisms remained to be elucidated. Here authors use biochemistry, X-ray crystallography and electrophsyiology and show that GABARAP directly binds to a previously unappreci...

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Autores principales: Jin Ye, Guichang Zou, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li, Wei Xiong, Chao Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7601d2b73eeb4f368fd223c36dd2f3fb
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