Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.

<h4>Background</h4>Influenza vaccine effectiveness (VE) studies are usually conducted by specialized agencies and require time and resources. The objective of this study was to estimate the influenza VE against medically attended influenza using a test-negative case-control design with r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Motoi Suzuki, Hiroyuki Yoshimine, Yoshitaka Harada, Naho Tsuchiya, Ikumi Shimada, Koya Ariyoshi, Kenichiro Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76050faec1524634a1066592f743e369
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76050faec1524634a1066592f743e369
record_format	dspace
spelling	oai:doaj.org-article:76050faec1524634a1066592f743e3692021-11-18T08:01:54ZEstimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.1932-620310.1371/journal.pone.0052103https://doaj.org/article/76050faec1524634a1066592f743e3692013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23326324/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Influenza vaccine effectiveness (VE) studies are usually conducted by specialized agencies and require time and resources. The objective of this study was to estimate the influenza VE against medically attended influenza using a test-negative case-control design with rapid influenza diagnostic tests (RIDT) in a clinical setting.<h4>Methods</h4>A prospective study was conducted at a community hospital in Nagasaki, western Japan during the 2010/11 influenza season. All outpatients aged 15 years and older with influenza-like illnesses (ILI) who had undergone RIDT were enrolled. A test-negative case-control design was applied to estimate the VEs: the cases were ILI patients with positive RIDT results and the controls were ILI patients with negative RIDT results. Information on patient characteristics, including vaccination histories, was collected using questionnaires and medical records.<h4>Results</h4>Between December 2010 and April 2011, 526 ILI patients were tested with RIDT, and 476 were eligible for the analysis. The overall VE estimate against medically attended influenza was 47.6%, after adjusting for the patients' age groups, presence of chronic conditions, month of visit, and smoking and alcohol use. The seasonal influenza vaccine reduced the risk of medically attended influenza by 60.9% for patients less than 50 years of age, but a significant reduction was not observed for patients 50 years of age and older. A sensitivity analysis provided similar figures.<h4>Conclusion</h4>The test-negative case-control study using RIDT provided moderate influenza VE consistent with other reports. Utilizing the commonly used RIDT to estimate VE provides rapid assessment of VE; however, it may require validation with more specific endpoint.Motoi SuzukiHiroyuki YoshimineYoshitaka HaradaNaho TsuchiyaIkumi ShimadaKoya AriyoshiKenichiro InouePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52103 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motoi Suzuki Hiroyuki Yoshimine Yoshitaka Harada Naho Tsuchiya Ikumi Shimada Koya Ariyoshi Kenichiro Inoue Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
description	<h4>Background</h4>Influenza vaccine effectiveness (VE) studies are usually conducted by specialized agencies and require time and resources. The objective of this study was to estimate the influenza VE against medically attended influenza using a test-negative case-control design with rapid influenza diagnostic tests (RIDT) in a clinical setting.<h4>Methods</h4>A prospective study was conducted at a community hospital in Nagasaki, western Japan during the 2010/11 influenza season. All outpatients aged 15 years and older with influenza-like illnesses (ILI) who had undergone RIDT were enrolled. A test-negative case-control design was applied to estimate the VEs: the cases were ILI patients with positive RIDT results and the controls were ILI patients with negative RIDT results. Information on patient characteristics, including vaccination histories, was collected using questionnaires and medical records.<h4>Results</h4>Between December 2010 and April 2011, 526 ILI patients were tested with RIDT, and 476 were eligible for the analysis. The overall VE estimate against medically attended influenza was 47.6%, after adjusting for the patients' age groups, presence of chronic conditions, month of visit, and smoking and alcohol use. The seasonal influenza vaccine reduced the risk of medically attended influenza by 60.9% for patients less than 50 years of age, but a significant reduction was not observed for patients 50 years of age and older. A sensitivity analysis provided similar figures.<h4>Conclusion</h4>The test-negative case-control study using RIDT provided moderate influenza VE consistent with other reports. Utilizing the commonly used RIDT to estimate VE provides rapid assessment of VE; however, it may require validation with more specific endpoint.
format	article
author	Motoi Suzuki Hiroyuki Yoshimine Yoshitaka Harada Naho Tsuchiya Ikumi Shimada Koya Ariyoshi Kenichiro Inoue
author_facet	Motoi Suzuki Hiroyuki Yoshimine Yoshitaka Harada Naho Tsuchiya Ikumi Shimada Koya Ariyoshi Kenichiro Inoue
author_sort	Motoi Suzuki
title	Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
title_short	Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
title_full	Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
title_fullStr	Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
title_full_unstemmed	Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.
title_sort	estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in japan.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/76050faec1524634a1066592f743e369
work_keys_str_mv	AT motoisuzuki estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT hiroyukiyoshimine estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT yoshitakaharada estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT nahotsuchiya estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT ikumishimada estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT koyaariyoshi estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan AT kenichiroinoue estimatingtheinfluenzavaccineeffectivenessagainstmedicallyattendedinfluenzainclinicalsettingsahospitalbasedcasecontrolstudywitharapiddiagnostictestinjapan
_version_	1718422609203298304

Estimating the influenza vaccine effectiveness against medically attended influenza in clinical settings: a hospital-based case-control study with a rapid diagnostic test in Japan.

Ejemplares similares