The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases
Introduction: Almost all causes of chronic liver damage can culminate in liver fibrosis and ultimately cirrhosis. Studies have suggested a relationship between mean platelet volume (MPV) and liver fibrosis; however, this needs confirmation by further studies. We here assessed the predictive value of...
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Zabol University of Medical sciences
2020
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oai:doaj.org-article:760b18f49e4c47e78ecb45c6b2fff79d2021-11-17T09:54:52ZThe Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases2476-664X10.34172/ijbsm.2020.23https://doaj.org/article/760b18f49e4c47e78ecb45c6b2fff79d2020-12-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-21482https://doaj.org/toc/2476-664XIntroduction: Almost all causes of chronic liver damage can culminate in liver fibrosis and ultimately cirrhosis. Studies have suggested a relationship between mean platelet volume (MPV) and liver fibrosis; however, this needs confirmation by further studies. We here assessed the predictive value of MPV for liver fibrosis in children with chronic liver diseases. Methods: In this study, children <18 years old with chronic liver diseases referred to the Nemazee Hospital of Shiraz during 2013-2016 were studied. The patients underwent liver biopsy for assessing liver fibrosis. Statistical analyses were conducted in SPSS 23. Results: From 368 studied children, 52.2% were boys. The patients’ mean age was 4.5±3.9 years old. Most patients had grade 6 fibrosis (36.7%). Cryptogenic (42.7%) was the most common cause of chronic liver disease, and jaundice was the most prevalent clinical presentation (53%). There was a significant association between the liver fibrosis and MPV (P=0.025). Conclusion: MPV was significantly different between patients with different severities of liver fibrosis. However, assigning an appropriate cut off value to distinguish different degrees of fibrosis requires more studies.Seyed Mohsen DehghaniMohammad Reza BordbarRezvan SalimiIraj ShahramianHadi MirzaeSiavash GholamiFatemeh SharafiAli BaziMaryam AtaollahiFatemeh FazeliSamaneh HamzelooZabol University of Medical sciencesarticlechronic liver disease liver fibrosis mean platelet volume Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 4, Pp 131-135 (2020) |
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chronic liver disease liver fibrosis mean platelet volume Medicine (General) R5-920 |
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chronic liver disease liver fibrosis mean platelet volume Medicine (General) R5-920 Seyed Mohsen Dehghani Mohammad Reza Bordbar Rezvan Salimi Iraj Shahramian Hadi Mirzae Siavash Gholami Fatemeh Sharafi Ali Bazi Maryam Ataollahi Fatemeh Fazeli Samaneh Hamzeloo The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| description |
Introduction: Almost all causes of chronic liver damage can culminate in liver fibrosis and ultimately cirrhosis. Studies have suggested a relationship between mean platelet volume (MPV) and liver fibrosis; however, this needs confirmation by further studies. We here assessed the predictive value of MPV for liver fibrosis in children with chronic liver diseases. Methods: In this study, children <18 years old with chronic liver diseases referred to the Nemazee Hospital of Shiraz during 2013-2016 were studied. The patients underwent liver biopsy for assessing liver fibrosis. Statistical analyses were conducted in SPSS 23. Results: From 368 studied children, 52.2% were boys. The patients’ mean age was 4.5±3.9 years old. Most patients had grade 6 fibrosis (36.7%). Cryptogenic (42.7%) was the most common cause of chronic liver disease, and jaundice was the most prevalent clinical presentation (53%). There was a significant association between the liver fibrosis and MPV (P=0.025). Conclusion: MPV was significantly different between patients with different severities of liver fibrosis. However, assigning an appropriate cut off value to distinguish different degrees of fibrosis requires more studies. |
| format |
article |
| author |
Seyed Mohsen Dehghani Mohammad Reza Bordbar Rezvan Salimi Iraj Shahramian Hadi Mirzae Siavash Gholami Fatemeh Sharafi Ali Bazi Maryam Ataollahi Fatemeh Fazeli Samaneh Hamzeloo |
| author_facet |
Seyed Mohsen Dehghani Mohammad Reza Bordbar Rezvan Salimi Iraj Shahramian Hadi Mirzae Siavash Gholami Fatemeh Sharafi Ali Bazi Maryam Ataollahi Fatemeh Fazeli Samaneh Hamzeloo |
| author_sort |
Seyed Mohsen Dehghani |
| title |
The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| title_short |
The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| title_full |
The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| title_fullStr |
The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| title_full_unstemmed |
The Predictive Value of Mean Platelet Volume for Liver Fibrosis in Children With Chronic Liver Diseases |
| title_sort |
predictive value of mean platelet volume for liver fibrosis in children with chronic liver diseases |
| publisher |
Zabol University of Medical sciences |
| publishDate |
2020 |
| url |
https://doaj.org/article/760b18f49e4c47e78ecb45c6b2fff79d |
| work_keys_str_mv |
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